MRPS9

MRPS9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS9, MRP-S9, RPMS9, S9mt, mitochondrial ribosomal protein S9
External IDs	MGI: 1916777 HomoloGene: 32565 GeneCards: MRPS9
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 105,037,983 bp[1] End 105,099,960 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 42,851,233 bp[2] End 42,905,683 bp[2]
Gene ontology Molecular function • protein binding • structural constituent of ribosome • RNA binding Cellular component • mitochondrial inner membrane • ribosome • intracellular ribonucleoprotein complex • nucleolus • mitochondrial small ribosomal subunit • mitochondrion Biological process • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • mitochondrial translational elongation • mitochondrial translational termination • DNA damage response, detection of DNA damage • translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64965	69527
Ensembl	ENSG00000135972	ENSMUSG00000060679
UniProt	P82933	Q9D7N3
RefSeq (mRNA)	NM_182640	NM_023514
RefSeq (protein)	NP_872578	NP_076003
Location (UCSC)	Chr 2: 105.04 – 105.1 Mb	Chr 1: 42.85 – 42.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene. ^[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008].

See also

• Mitochondrial ribosome

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.