MRPL30

MRPL30
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDsMGI: 1333820 HomoloGene: 32675 GeneCards: MRPL30
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q11.2Start99,181,079 bp[1]
End99,197,626 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51263

107734

Ensembl

ENSG00000185414

ENSMUSG00000026087

UniProt

Q8TCC3

Q9D7N6

RefSeq (mRNA)

NM_016503
NM_145212
NM_145213

NM_027098
NM_001356482

RefSeq (protein)

NP_660213

NP_081374
NP_001343411

Location (UCSC)Chr 2: 99.18 – 99.2 MbChr 1: 37.89 – 37.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185414 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026087 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: MRPL30 mitochondrial ribosomal protein L30".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, Wittmann-Liebold B, Grohmann L, Graack HR (December 1998). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". The Journal of Biological Chemistry. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
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