60S ribosomal protein L41

RPL41
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPL41, L41, ribosomal protein L41
External IDsGeneCards: RPL41
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.2Start56,116,586 bp[1]
End56,117,943 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6171

n/a

Ensembl

ENSG00000229117

n/a

UniProt

P62945

n/a

RefSeq (mRNA)

NM_021104
NM_001035267

n/a

RefSeq (protein)

NP_001030344
NP_066927

n/a

Location (UCSC)Chr 12: 56.12 – 56.12 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

60S ribosomal protein L41 is a protein that in humans is encoded by the RPL41 gene.[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000229117 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Klaudiny J, von der Kammer H, Scheit KH (Oct 1992). "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41". Biochem Biophys Res Commun. 187 (2): 901–6. doi:10.1016/0006-291X(92)91282-U. PMID 1326959.
  4. ↑ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  5. 1 2 "Entrez Gene: RPL41 ribosomal protein L41".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
  • Lee JH, Kim JM, Kim MS, et al. (1997). "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII". Biochem. Biophys. Res. Commun. 238 (2): 462–7. doi:10.1006/bbrc.1997.7317. PMID 9299532.
  • Go H, Miyado K, Taniguchi S (1999). "Genomic structure of the human ribosomal protein L41 gene". Biochem. Mol. Biol. Int. 46 (6): 1227–31. doi:10.1080/15216549800204792. PMID 9891856.
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
  • Ahn BH, Kim TH, Bae YS (2002). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. 12 (2): 158–63. PMID 11710515.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
  • Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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