MRPS25

MRPS25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS25, MRP-S25, RPMS25, mitochondrial ribosomal protein S25
External IDsMGI: 1928140 HomoloGene: 11207 GeneCards: MRPS25
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p25.1Start15,042,460 bp[1]
End15,065,335 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64432

64658

Ensembl

ENSG00000131368

ENSMUSG00000014551

UniProt

P82663

Q9D125

RefSeq (mRNA)

NM_022497

NM_025578

RefSeq (protein)

NP_071942

NP_079854

Location (UCSC)Chr 3: 15.04 – 15.07 MbChr 6: 92.17 – 92.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S25, mitochondrial is a protein that in humans is encoded by the MRPS25 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131368 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014551 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. 1 2 "Entrez Gene: MRPS25 mitochondrial ribosomal protein S25".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
  • Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi:10.1074/jbc.M003596200. PMID 10938081.
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