60S ribosomal protein L26

RPL26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O
Identifiers
Aliases	RPL26, DBA11, L26, ribosomal protein L26
External IDs	MGI: 106022 HomoloGene: 113207 GeneCards: RPL26
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	8,383,250 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	68,906,989 bp[2]
Gene ontology
Molecular function	• protein binding; • RNA binding; • structural constituent of ribosome; • mRNA 5'-UTR binding;
Cellular component	• cytosol; • ribosome; • membrane; • large ribosomal subunit; • intracellular ribonucleoprotein complex; • intracellular; • cytosolic large ribosomal subunit; • extracellular exosome; • nucleoplasm; • nucleolus; • cytoplasm; • cytosolic ribosome; • Q22327404;
Biological process	• translation; • viral transcription; • SRP-dependent cotranslational protein targeting to membrane; • ribosomal large subunit biogenesis; • translational initiation; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • rRNA processing; • cytoplasmic translation; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • cellular response to UV; • positive regulation of translation; • cellular response to ionizing radiation; • cellular response to gamma radiation; • positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of translation involved in cellular response to UV;
	Sources:Amigo / QuickGO
Orthologs
	6154
	19941
	ENSG00000161970
	ENSMUSG00000060938
	P61254
	P61255
	NM_000987; NM_001315530; NM_001315531
	NM_009080
	NP_000978; NP_001302459; NP_001302460
	NP_033106
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.^[5]^[6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions

RPL26 has been shown to interact with Mdm2.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161970 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060938 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Zaman GJ (May 1993). "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic Acids Res. 21 (7): 1673. doi:10.1093/nar/21.7.1673. PMC 309386. PMID 8479925.
1 2 "Entrez Gene: RPL26 ribosomal protein L26".
↑ Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M (Oct 2008). "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26". Mol. Cell. 32 (2): 180–9. doi:10.1016/j.molcel.2008.08.031. PMC 2587494. PMID 18951086.

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161970 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060938 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8479925-5] Zaman GJ (May 1993). "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic Acids Res. 21 (7): 1673. doi:10.1093/nar/21.7.1673. PMC 309386. PMID 8479925.

[entrez-6] 1 2 "Entrez Gene: RPL26 ribosomal protein L26".

[pmid18951086-7] Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M (Oct 2008). "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26". Mol. Cell. 32 (2): 180–9. doi:10.1016/j.molcel.2008.08.031. PMC 2587494. PMID 18951086.

60S ribosomal protein L26

Function

Interactions

References

Further reading