EIF4E3

EIF4E3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B6U, 4B6V
Identifiers
Aliases	EIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3
External IDs	MGI: 1914142 HomoloGene: 41652 GeneCards: EIF4E3
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	71,754,773 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	99,666,771 bp[2]
Gene ontology
Molecular function	• translation initiation factor activity; • RNA binding;
Cellular component	• cytoplasm; • cytosol; • mRNA cap binding complex;
Biological process	• translational initiation; • regulation of translation; • translation;
	Sources:Amigo / QuickGO
Orthologs
	317649
	66892
	ENSG00000163412
	ENSMUSG00000093661
	Q8N5X7
	Q9DBB5
	NM_001134649; NM_001134650; NM_001134651; NM_001282886; NM_173359
	NM_025829
	NP_001128121; NP_001128122; NP_001128123; NP_001269815; NP_775495
	NP_080105
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.^[5]

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.^[5]^[6]

Model organisms

*Eif4e3* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Salmonella infection	Normal^[7]
Citrobacter infection	Normal^[8]
All tests and analysis from^[9]^[10]

Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3^{tm1a(KOMP)Wtsi}^[11]^[12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[13]^[14]^[15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[9]^[16] Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.
↑ Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
↑ "Salmonella infection data for Eif4e3". Wellcome Trust Sanger Institute.
↑ "Citrobacter infection data for Eif4e3". Wellcome Trust Sanger Institute.
1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248): 0. doi:10.1111/j.1755-3768.2010.4142.x.
↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
↑ "International Knockout Mouse Consortium".
↑ "Mouse Genome Informatics".
↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.

[6] Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.

[''Salmonella''_infection-7] "Salmonella infection data for Eif4e3". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-8] "Citrobacter infection data for Eif4e3". Wellcome Trust Sanger Institute.

[mgp_reference-9] 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248): 0. doi:10.1111/j.1755-3768.2010.4142.x.

[10] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-11] "International Knockout Mouse Consortium".

[mgi_allele_ref-12] "Mouse Genome Informatics".

[pmid21677750-13] Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-14] Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-15] Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.

[pmid21722353-16] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.