Mitochondrial ribosomal protein L41

MRPL41
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL41, BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41
External IDsMGI: 1333816 HomoloGene: 13036 GeneCards: MRPL41
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.3Start137,551,199 bp[1]
End137,552,555 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64975

107733

Ensembl

ENSG00000182154

ENSMUSG00000036850

UniProt

Q8IXM3

Q9CQN7

RefSeq (mRNA)

NM_032477

NM_001031808

RefSeq (protein)

NP_115866

NP_001026978

Location (UCSC)Chr 9: 137.55 – 137.55 MbChr 2: 24.97 – 24.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182154 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036850 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. 1 2 "Entrez Gene: MRPL41 mitochondrial ribosomal protein L41".

Further reading

  • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
  • Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chintharlapalli SR, Jasti M, Malladi S, et al. (2005). "BMRP is a Bcl-2 binding protein that induces apoptosis". J. Cell. Biochem. 94 (3): 611–26. doi:10.1002/jcb.20292. PMID 15547950.
  • Yoo YA, Kim MJ, Park JK, et al. (2005). "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1". Mol. Cell. Biol. 25 (15): 6603–16. doi:10.1128/MCB.25.15.6603-6616.2005. PMC 1190350. PMID 16024796.
  • Kim MJ, Yoo YA, Kim HJ, et al. (2006). "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)". Biochem. Biophys. Res. Commun. 338 (2): 1179–84. doi:10.1016/j.bbrc.2005.10.064. PMID 16256947.
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