TRPM6

TRPM6
Identifiers
Aliases	TRPM6, CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6
External IDs	OMIM: 607009 MGI: 2675603 HomoloGene: 9767 GeneCards: TRPM6
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	74,888,094 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	18,892,511 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • ion channel activity; • GO:0001948 protein binding; • cation channel activity; • ATP binding; • calcium channel activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • brush border membrane; • apical plasma membrane;
Biological process	• phosphorylation; • metal ion transport; • cation transport; • ion transport; • protein tetramerization; • protein phosphorylation; • calcium ion transmembrane transport; • response to toxic substance; • calcium ion transport; • transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	140803
	225997
	ENSG00000119121
	ENSMUSG00000024727
	Q9BX84
	Q8CIR4
	NM_001177310; NM_001177311; NM_017662
	NM_153417
	NP_001170781; NP_001170782; NP_060132
	NP_700466
	Wikidata
View/Edit Human	View/Edit Mouse

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[5]

References

GRCh38: Ensembl release 89: ENSG00000119121 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024727 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568.

TRPM6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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