CACNA1G

CACNA1G
Identifiers
Aliases	CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G, SCA42ND
External IDs	OMIM: 604065 MGI: 1201678 HomoloGene: 22544 GeneCards: CACNA1G
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	50,627,474 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	94,474,198 bp[2]
Gene ontology
Molecular function	• voltage-gated calcium channel activity; • calcium channel activity; • scaffold protein binding; • voltage-gated ion channel activity; • ion channel activity; • voltage-gated calcium channel activity involved in AV node cell action potential; • voltage-gated calcium channel activity involved SA node cell action potential; • low voltage-gated calcium channel activity; • voltage-gated sodium channel activity;
Cellular component	• integral component of membrane; • membrane; • voltage-gated calcium channel complex; • cytoplasm; • cell membrane;
Biological process	• membrane depolarization during action potential; • calcium ion import; • regulation of membrane potential; • regulation of ion transmembrane transport; • regulation of atrial cardiac muscle cell membrane depolarization; • ion transport; • regulation of heart rate; • positive regulation of calcium ion-dependent exocytosis; • transmembrane transport; • action potential; • response to nickel cation; • calcium ion transport; • chemical synaptic transmission; • AV node cell to bundle of His cell signaling; • regulation of heart rate by cardiac conduction; • SA node cell action potential; • AV node cell action potential; • SA node cell to atrial cardiac muscle cell signaling; • membrane depolarization during AV node cell action potential; • calcium ion transmembrane transport; • membrane depolarization during SA node cell action potential; • cardiac muscle cell action potential involved in contraction; • neuronal action potential; • sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8913
	12291
	ENSG00000006283
	ENSMUSG00000020866
	O43497
	n/a
NM_001256324; NM_001256325; NM_001256326; NM_001256327; NM_001256328;
	NM_001256329; NM_001256330; NM_001256331; NM_001256332; NM_001256333; NM_001256334; NM_001256359; NM_001256360; NM_001256361; NM_018896; NM_198376; NM_198377; NM_198378; NM_198379; NM_198380; NM_198382; NM_198383; NM_198384; NM_198385; NM_198386; NM_198387; NM_198388; NM_198396; NM_198397
	NM_001112813; NM_001177888; NM_001177890; NM_009783
NP_001243253; NP_001243254; NP_001243255; NP_001243256; NP_001243257;
	NP_001243258; NP_001243259; NP_001243260; NP_001243261; NP_001243262; NP_001243263; NP_001243288; NP_001243289; NP_001243290; NP_061496; NP_938190; NP_938191; NP_938192; NP_938193; NP_938194; NP_938196; NP_938197; NP_938198; NP_938199; NP_938200; NP_938201; NP_938202; NP_938406
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca_v3.1 is a protein which in humans is encoded by the CACNA1G gene.[5][6][7] It is one of the primary targets in the pharmacology of absence seizure.

Function

Ca_v3.1 is a type of low-voltage-activated calcium channel, also known as "T-type" for its transient on and off[5]. It is expressed in thalamocortical relay nucleus, and is responsible for the slow-wave sleep and absence seizure[8]. During a slow-wave sleep, Ca_v3.1 is put into burst mode, and a self-sustaining synchronous cycle between cortex and thalamus is formed, sensory inputs are isolated from cortex; while awake the thalamus should instead relay sensory inputs from outside the central nervous system. The mechanism of absence seizure has a lot in common with slow-wave sleep. Therefore, a blocker that inhibits the burst mode activation of Ca_v3.1 is effective in treating absence seizures. Common drugs including ethosuximide, as well as trimethadione[8].

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]

[[File:

[[<div style="display:block; width:38px; height:0px; overflow:hidden; position:relative; left:396.0px; top:221px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63px; height:0px; overflow:hidden; position:relative; left:307.0px; top:124px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:67.5px; top:295px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:168.0px; top:259px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:38px; height:0px; overflow:hidden; position:relative; left:396.0px; top:62px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:375.0px; top:356px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:61px; height:0px; overflow:hidden; position:relative; left:107.0px; top:228px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:61px; height:0px; overflow:hidden; position:relative; left:107.0px; top:208px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:33px; height:0px; overflow:hidden; position:relative; left:67.0px; top:259px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:57px; height:0px; overflow:hidden; position:relative; left:25.0px; top:177px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63px; height:0px; overflow:hidden; position:relative; left:307.0px; top:144px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:32px; height:0px; overflow:hidden; position:relative; left:168.0px; top:295px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:591.0px; top:356px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:56px; height:12px; overflow:hidden; position:relative; left:307.0px; top:107px; background:transparent; border:4px black solid"></div>]]

|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

References

GRCh38: Ensembl release 89: ENSG00000006283 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020866 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342.
Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.
Kopecky, Benjamin J.; Liang, Ruqiang; Bao, Jianxin (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". Pflügers Archiv. 466 (4): 757–765. doi:10.1007/s00424-014-1454-x. ISSN 0031-6768. PMC 4005039. PMID 24563219.

External links

CACNA1G+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CACNA1G genome location and CACNA1G gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[WikiPathways-9] The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006283 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020866 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".

[pmid9495342-6] Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342.

[pmid16382099-7] Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.

[t-type-8] Kopecky, Benjamin J.; Liang, Ruqiang; Bao, Jianxin (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". Pflügers Archiv. 466 (4): 757–765. doi:10.1007/s00424-014-1454-x. ISSN 0031-6768. PMC 4005039. PMID 24563219.

CACNA1G

Function

Interactive pathway map

See also

References

External links