TRPM3

TRPM3
Identifiers
Aliases	TRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDs	OMIM: 608961 MGI: 2443101 HomoloGene: 62287 GeneCards: TRPM3
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	71,446,904 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	22,995,410 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• ion channel activity; • calcium activated cation channel activity; • cation channel activity; • calcium channel activity;
Cellular component	• integral component of membrane; • cell membrane; • membrane;
Biological process	• detection of temperature stimulus; • ion transport; • protein tetramerization; • sensory perception of temperature stimulus; • calcium ion transport; • ion transmembrane transport; • cation transport; • transmembrane transport; • calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	80036
	226025
	ENSG00000083067
	ENSMUSG00000052387
	Q9HCF6
	n/a
NM_001007470; NM_001007471; NM_020952; NM_024971; NM_206944;
	NM_206945; NM_206946; NM_206947; NM_206948; NM_001366141; NM_001366142; NM_001366143; NM_001366144; NM_001366145; NM_001366146; NM_001366147; NM_001366148; NM_001366149; NM_001366150; NM_001366151; NM_001366152; NM_001366153; NM_001366154
NM_001035239; NM_001035240; NM_001035241; NM_001035242; NM_001035243;
	NM_001035244; NM_001035245; NM_001035246; NM_177341; NM_001362487; NM_001362488; NM_001362489; NM_001362490; NM_001362491; NM_001362496; NM_001362497; NM_001362498; NM_001362499; NM_001362500; NM_001362501; NM_001362502; NM_001362503; NM_001362504; NM_001362505; NM_001362506; NM_001362507; NM_001362508; NM_001362511; NM_001362512; NM_001362513
NP_001007471; NP_001007472; NP_066003; NP_079247; NP_996827;
	NP_996828; NP_996829; NP_996830; NP_996831; NP_001353070; NP_001353071; NP_001353072; NP_001353073; NP_001353074; NP_001353075; NP_001353076; NP_001353077; NP_001353078; NP_001353079; NP_001353080; NP_001353081; NP_001353082; NP_001353083
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[5]

Function

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[6] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[7]

TRPM3 Ligands

Channel Blockers

Mefenamic acid[8]
Citrus fruit flavonoids, E.g. Naringenin and hesperetin, as well as Ononetin (a deoxybenzoin).[9]

Agonist

CIM0216

References

GRCh38: Ensembl release 89: ENSG00000083067 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052387 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
"Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.
Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C (April 2011). "Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3". British Journal of Pharmacology. 162 (8): 1757–69. doi:10.1111/j.1476-5381.2010.01186.x. PMC 3081119. PMID 21198543.
Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M (April 2013). "Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3". British Journal of Pharmacology. 168 (8): 1835–50. doi:10.1111/bph.12076. PMC 3623054. PMID 23190005.

External links

TRPM3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083067 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052387 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382100-5] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

[6] "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".

[pmid18978782-7] Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.

[KloseStraub2011-8] Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C (April 2011). "Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3". British Journal of Pharmacology. 162 (8): 1757–69. doi:10.1111/j.1476-5381.2010.01186.x. PMC 3081119. PMID 21198543.

[StraubMohr2013-9] Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M (April 2013). "Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3". British Journal of Pharmacology. 168 (8): 1835–50. doi:10.1111/bph.12076. PMC 3623054. PMID 23190005.