Calsenilin

KCNIP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6W
Identifiers
Aliases	KCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDs	OMIM: 604662 MGI: 1929258 HomoloGene: 8382 GeneCards: KCNIP3
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	95,386,077 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	127,522,094 bp[2]
Gene ontology
Molecular function	• DNA binding; • calcium ion binding; • sequence-specific DNA binding; • potassium channel activity; • GO:0001106 transcription corepressor activity; • voltage-gated ion channel activity; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948 protein binding; • potassium channel regulator activity; • ion channel binding;
Cellular component	• cytoplasm; • axon terminus; • cytosol; • Golgi apparatus; • membrane; • voltage-gated potassium channel complex; • axon; • dendrite; • protein-DNA complex; • endoplasmic reticulum; • cell nucleus; • cell membrane;
Biological process	• regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • regulation of ion transmembrane transport; • negative regulation of transcription from RNA polymerase II promoter; • ion transport; • transcription, DNA-templated; • potassium ion transport; • potassium ion transmembrane transport; • protein localization to plasma membrane; • intracellular protein transport; • regulation of potassium ion transmembrane transport; • signal transduction; • apoptotic process; • negative regulation of nucleic acid-templated transcription; • cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	30818
	56461
	ENSG00000115041
	ENSMUSG00000079056
	Q9Y2W7
	Q9QXT8; P0C092
	NM_001034914; NM_013434
	NM_001111331; NM_001291005; NM_019789
	NP_001030086; NP_038462
	NP_001104801; NP_001277934; NP_062763
	Wikidata
View/Edit Human	View/Edit Mouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[5][6][7]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[8][9] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.[10] Alternatively spliced transcript variants encoding different isoforms have been described.[7]

Interactions

Calsenilin has been shown to interact with PSEN1[5][11] and PSEN2.[5][12]

References

GRCh38: Ensembl release 89: ENSG00000115041 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079056 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752.
Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534.
"Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".
Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 24487321.
Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253.
Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

External links

KCNIP3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
NCS proteins

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115041 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079056 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9771752-5] Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752.

[pmid10078534-6] Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534.

[entrez-7] "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".

[pmid17311005-8] Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

[pmid15046879-9] Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.

[PMC4005385-10] Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 24487321.

[pmid10854253-11] Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253.

[pmid11278424-12] Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

Calsenilin

Function

Interactions

See also

References

Further reading

External links