TRPM4

TRPM4
Identifiers
Aliases	TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6
External IDs	OMIM: 606936 MGI: 1915917 HomoloGene: 23033 GeneCards: TRPM4
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	49,211,836 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	45,333,780 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • calcium channel activity; • calmodulin binding; • ion channel activity; • ATP binding; • sodium channel activity; • calcium activated cation channel activity; • calcium ion binding; • metal ion binding;
Cellular component	• integral component of membrane; • Golgi apparatus; • membrane; • cell membrane; • nucleoplasm; • endoplasmic reticulum; • cytosol; • neuronal cell body; • sodium channel complex; • spanning component of plasma membrane; • spanning component of membrane;
Biological process	• adaptive immune response; • vasoconstriction; • immune system process; • positive regulation of canonical Wnt signaling pathway; • regulation of membrane potential; • cation transport; • ion transport; • protein sumoylation; • dendritic cell chemotaxis; • regulation of T cell cytokine production; • cardiac conduction; • positive regulation of cell proliferation; • calcium ion transport; • negative regulation of bone mineralization; • positive regulation of atrial cardiac muscle cell action potential; • positive regulation of heart rate; • transmembrane transport; • positive regulation of adipose tissue development; • positive regulation of cytosolic calcium ion concentration; • calcium ion transmembrane transport; • positive regulation of fat cell differentiation; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • negative regulation of osteoblast differentiation; • positive regulation of vasoconstriction; • positive regulation of regulation of vascular smooth muscle cell membrane depolarization; • ion transmembrane transport; • calcium-mediated signaling; • membrane depolarization during AV node cell action potential; • membrane depolarization during Purkinje myocyte cell action potential; • membrane depolarization during bundle of His cell action potential; • regulation of heart rate by cardiac conduction; • sodium ion import across plasma membrane; • regulation of ventricular cardiac muscle cell action potential; • protein homotetramerization; • cellular response to ATP; • inorganic cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54795
	68667
	ENSG00000130529
	ENSMUSG00000038260
	Q8TD43
	Q7TN37
NM_001195227; NM_017636; NM_001321281; NM_001321282; NM_001321283;
	NM_001321285
	NM_175130
NP_001182156; NP_001308210; NP_001308211; NP_001308212; NP_001308214;
	NP_060106
	NP_780339
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.[5][6]

TRPM4 Channel Blocker

9-Phenanthrol

References

GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

External links

TRPM4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11535825-5] Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

TRPM4

TRPM4 Channel Blocker

See also

References

Further reading

External links