KCNAB1

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.[5][6][7]

KCNAB1
Identifiers
AliasesKCNAB1, AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3, potassium voltage-gated channel subfamily A member regulatory beta subunit 1
External IDsOMIM: 601141 MGI: 109155 HomoloGene: 56491 GeneCards: KCNAB1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.31Start156,037,701 bp[1]
End156,539,138 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7881

16497

Ensembl

ENSG00000169282

ENSMUSG00000027827

UniProt

Q14722
Q5MJQ3

P63143

RefSeq (mRNA)

NM_001308217
NM_001308222
NM_003471
NM_172159
NM_172160

NM_001289450
NM_010597
NM_001357358

RefSeq (protein)

NP_001276379
NP_034727
NP_001344287

Location (UCSC)Chr 3: 156.04 – 156.54 MbChr 3: 64.95 – 65.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000169282 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027827 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics. 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324.
  6. England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM (Jan 1996). "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing". J Biol Chem. 270 (48): 28531–4. doi:10.1074/jbc.270.48.28531. PMID 7499366.
  7. "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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