CLIC6

CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321 MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6
Gene location (Human)
Chr.	Chromosome 21 (human)[1]
End	34,718,227 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	92,541,243 bp[2]
Gene ontology
Molecular function	• voltage-gated ion channel activity; • glutathione transferase activity; • chloride channel activity; • D2 dopamine receptor binding; • D3 dopamine receptor binding; • D4 dopamine receptor binding;
Cellular component	• integral component of membrane; • cell membrane; • extracellular exosome; • membrane; • chloride channel complex; • cell nucleus; • cytoplasm;
Biological process	• regulation of ion transmembrane transport; • chloride transport; • ion transport; • glutathione metabolic process; • chloride transmembrane transport; • transport; • ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54102
	209195
	ENSG00000159212
	ENSMUSG00000022949
	Q96NY7
	Q8BHB9
	NM_053277; NM_001317009
	NM_172469
	NP_001303938; NP_444507
	NP_766057
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.[7]

References

GRCh38: Ensembl release 89: ENSG00000159212 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022949 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
"Entrez Gene: CLIC6 chloride intracellular channel 6".
Griffon, Nathalie; Jeanneteau Freddy; Prieur Fanny; Diaz Jorge; Sokoloff Pierre (Sep 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. ISSN 0169-328X. PMID 14499480.

External links

CLIC6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159212 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022949 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10830953-5] Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.

[entrez-6] "Entrez Gene: CLIC6 chloride intracellular channel 6".

[pmid14499480-7] Griffon, Nathalie; Jeanneteau Freddy; Prieur Fanny; Diaz Jorge; Sokoloff Pierre (Sep 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. ISSN 0169-328X. PMID 14499480.

CLIC6

Interactions

See also

References

Further reading

External links