Guanosine diphosphate

Guanosine diphosphate
Identifiers
CAS Number	146-91-8 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:17552 ;
ChEMBL	ChEMBL384759 ;
ChemSpider	8630 ;
IUPHAR/BPS	2410;
PubChem CID	730;
CompTox Dashboard (EPA)	DTXSID90163254 ;
	InChI InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 Key: QGWNDRXFNXRZMB-UUOKFMHZSA-N ;
	SMILES C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)NC(=NC2=O)N;
Properties
Chemical formula	C10H15N5O11P2
Molar mass	443.200522
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of a pyrophosphate group, a pentose sugar ribose, and the nucleobase guanine.[1]

GDP is the product of GTP dephosphorylation by GTPases, e.g., the G-proteins that are involved in signal transduction.

GDP is converted into GTP with the help of pyruvate kinase and phosphoenolpyruvate.

References

Crane, Laura J; Miller, David Lee (1974). "Guanosine triphosphate and guanosine diphosphate as conformation-determining molecules. Differential interaction of a fluorescent probe with the guanosine nucleotide complexes of bacterial elongation factor Tu". Biochemistry. 13 (5): 933–939. doi:10.1021/bi00702a017.

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