Triprolidine
Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]
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| Trade names | Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Oral |
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| Bioavailability | 4% oral |
| Protein binding | 90% |
| Metabolism | Hepatic (CYP2D6) |
| Elimination half-life | 4–6 hours |
| Excretion | Renal |
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| ECHA InfoCard | 100.006.934  |
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| Formula | C19H22N2 |
| Molar mass | 278.399 g·mol−1 |
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| Melting point | 60 °C (140 °F) |
| Solubility in water | 500 mg/mL (20 °C) |
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It was patented in 1948 and came into medical use in 1953.[3]
References
- Goldsmith P, Dowd PM (January 1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic Clinics. 11 (1): 87–95. PMID 8094649.
- Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical Pharmacy. 3 (6): 638–43. PMID 6509877.
- Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
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See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors | |
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See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators | |||||
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