Benactyzine

Benactyzine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-(diethylamino)ethyl hydroxy(diphenyl)acetate;
CAS Number	302-40-9 ;
PubChem CID	9330;
DrugBank	DB09023 ;
ChemSpider	8966 ;
UNII	595EG71R3F;
KEGG	D07498 ;
ChEMBL	ChEMBL70352 ;
CompTox Dashboard (EPA)	DTXSID0022644 ;
ECHA InfoCard	100.005.568
Chemical and physical data
Formula	C20H25NO3
Molar mass	327.424 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCN(CC)CC)C(O)(c1ccccc1)c2ccccc2;
	InChI InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3 ; Key:IVQOFBKHQCTVQV-UHFFFAOYSA-N ;
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Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness.[1]

Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.[1] "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD." [2]

Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence of effectiveness when combined with meprobamate, with the medication no longer available it is not clinically important.[3]

History

Benactyzine was brought to market in the US in 1957 by Merck under the tradename, Suavitil.[4]

References

Shorter, E., Looking backwards: a possible new path for drug discovery in psychopharmacology. Nat Rev Drug Discov 2002, 1 (12), 1003–1006.
Fisher, Seymour (1959). Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.
DeBattista, Alan F. Schatzberg, Jonathan O. Cole, Charles (2010). Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 978-1-58562-377-8.
Smith, Mickey C., PhD. Principles of Pharmaceutical Marketing, Third Edition. 3rd ed. New York: Routledge, 2013. Print. ISBN 978-1-317-94071-5

External links

Media related to Benactyzine at Wikimedia Commons

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[Shorter-1] Shorter, E., Looking backwards: a possible new path for drug discovery in psychopharmacology. Nat Rev Drug Discov 2002, 1 (12), 1003–1006.

[2] Fisher, Seymour (1959). Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.

[3] DeBattista, Alan F. Schatzberg, Jonathan O. Cole, Charles (2010). Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 978-1-58562-377-8.

[4] Smith, Mickey C., PhD. Principles of Pharmaceutical Marketing, Third Edition. 3rd ed. New York: Routledge, 2013. Print. ISBN 978-1-317-94071-5