NPR1

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

NPR1
Identifiers
AliasesNPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDsOMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start153,678,688 bp[1]
End153,693,992 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4881

18160

Ensembl

ENSG00000169418

ENSMUSG00000027931

UniProt

P16066

P18293

RefSeq (mRNA)

NM_000906

NM_008727

RefSeq (protein)

NP_000897

NP_032753

Location (UCSC)Chr 1: 153.68 – 153.69 MbChr 3: 90.45 – 90.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000169418 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027931 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  6. BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading
  • Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097.
  • Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian Heart Journal Supplement. 3 (11): 1085–91. PMID 12506509.
  • Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides. 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067.
  • Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides. 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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