Tanezumab

Tanezumab
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target NGF
Clinical data
Synonyms RN624
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
Formula C6464H9942N1706O2026S46
Molar mass 145.4 kg/mol
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Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor. It was developed by Pfizer as a treatment for pain.[1]

In 2009 there was a Phase III trial for knee pain due to osteoarthritis (OA).[2] Another Phase III trial for hip pain in OA [3] was halted in June 2010 when some patients needed hip replacement.[4]

Tanezumab is undergoing Phase II clinical trials for the treatment of various pain entities, including chronic low back pain, bone cancer pain, and interstitial cystitis.[5]

In March 2012, the Anti-NGF Testing - FDA Committee voted in favor of a continuation of the development of nerve-blocking medications, as long as certain safety precautions were observed.[6] [7]

A Phase III trial published in 2013 found tanezumab was superior to placebo for painful hip osteoarthritis.[8]

See also

References

  1. ↑ N05, American Medical Association.
  2. ↑ "Tanezumab in Osteoarthritis of the Knee". 2009
  3. ↑ "Tanezumab in Osteoarthritis Of The Hip".
  4. ↑ http://www.genengnews.com/gen-news-highlights/trials-halted-as-pfizer-s-tanezumab-shown-to-worsen-osteoarthritis/81243572/
  5. ↑ "Phase II trials involving Tanezumab".
  6. ↑ http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ArthritisAdvisoryCommittee/UCM295205.pdf
  7. ↑ http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/arthritisadvisorycommittee/ucm301305.pdf
  8. ↑ "Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial". Arthritis Rheum. 65: 1795–803. Jul 2013. doi:10.1002/art.37950. PMID 23553790.


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