Volociximab

Volociximab
Monoclonal antibody
Type Whole antibody
Source Chimeric (mouse/human)
Target α5β1 integrin
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
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UNII
KEGG
Chemical and physical data
Formula C6434H9942N1706O2040S52
Molar mass 145.5 kg/mol
 ☒N☑Y (what is this?)   (verify)

Volociximab (also known as M200) is a chimeric monoclonal antibody jointly developed by PDL BioPharma and Biogen Idec for treatment of a variety of advanced solid tumors. It binds to and inhibits the functional activity of α5β1 integrin.[1]

It is thought to reduce metastases. Early results show potential in renal cell cancers.

References

  1. ↑ Ng, CM; Bai, S; Takimoto, CH; Tang, MT; Tolcher, AW (2009). "Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-alpha(5)beta (1) integrin monoclonal antibody (volociximab) in cancer patients". Cancer chemotherapy and pharmacology. 65 (2): 207–17. doi:10.1007/s00280-009-1023-8. PMID 19468731.


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