Pyrimidine analogue
Pyrimidine analogues are nucleoside analog antimetabolites which mimic the structure of metabolic pyrimidines.
Examples
- 5-Fluorouracil (5FU) which inhibits thymidylate synthase.
- Floxuridine (FUDR)
- Cytarabine (Cytosine arabinoside)
- 6-azauracil (6-AU)
Medical Uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
- ↑ Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376.
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