Treosulfan

Treosulfan
Clinical data
Synonyms 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, Threitol 1,4-dimethanesulfonate, Threitol 1,4-bismethanesulfonate; L-Threitol 1,4-bis(methanesulfonate); Ovastat; Threosulphan; Treosulphan; Tresulfan
AHFS/Drugs.com International Drug Names
Routes of
administration		 Oral, IV
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.005.529 Edit this at Wikidata
Chemical and physical data
Formula C6H14O8S2
Molar mass 278.30056 g·mol−1
3D model (JSmol)
Melting point 101.5 to 105 °C (214.7 to 221.0 °F)
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Treosulfan is a substance that is being studied in the treatment of cancer.[1] It belongs to the family of drugs called alkylating agents. It has been used mainly as a substitute of busulfan in frail patients, as the side effects and toxicity are supposedly less severe.

References

  1. ↑ Schmittel A, Schmidt-Hieber M, Martus P, et al. (December 2006). "A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma". Ann. Oncol. 17 (12): 1826–9. doi:10.1093/annonc/mdl309. PMID 16971664.
  • Treosulfan entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".


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