Uramustine

Uramustine
Clinical data
ATC code	None;
Pharmacokinetic data
Protein binding	5%
Excretion	Renal
Identifiers
	IUPAC name 5-[bis(2-Chloroethyl)amino]-1H-pyrimidine-2,4-dione;
CAS Number	66-75-1 ;
PubChem CID	6194;
IUPHAR/BPS	7621;
DrugBank	DB00791 ;
ChemSpider	5959 ;
UNII	W7KQ46GJ8U;
KEGG	D06265 ;
ChEMBL	CHEMBL1488 ;
ECHA InfoCard	100.000.574
Chemical and physical data
Formula	C8H11Cl2N3O2
Molar mass	252.097 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1C(\N(CCCl)CCCl)=C/NC(=O)N1;
	InChI InChI=1S/C8H11Cl2N3O2/c9-1-3-13(4-2-10)6-5-11-8(15)12-7(6)14/h5H,1-4H2,(H2,11,12,14,15) ; Key:IDPUKCWIGUEADI-UHFFFAOYSA-N ;
(what is this?) (verify)

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.

References

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

Clinical data

ATC code	None
Pharmacokinetic data
Protein binding	5%
Excretion	Renal
Identifiers
IUPAC name 5-[bis(2-Chloroethyl)amino]-1H-pyrimidine-2,4-dione
CAS Number	66-75-1^Y
PubChem CID	6194
IUPHAR/BPS	7621
DrugBank	DB00791^N
ChemSpider	5959^N
UNII	W7KQ46GJ8U
KEGG	D06265^Y
ChEMBL	CHEMBL1488^N
ECHA InfoCard	100.000.574
Chemical and physical data
Formula	C₈H₁₁Cl₂N₃O₂
Molar mass	252.097 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1C(\N(CCCl)CCCl)=C/NC(=O)N1
InChI InChI=1S/C8H11Cl2N3O2/c9-1-3-13(4-2-10)6-5-11-8(15)12-7(6)14/h5H,1-4H2,(H2,11,12,14,15)^N Key:IDPUKCWIGUEADI-UHFFFAOYSA-N^N
^NY (what is this?) (verify)