Tromantadine

Tromantadine
Clinical data
Trade names	Viru-Merz
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical (gel)
ATC code	D06BB02 (WHO) J05AC03 (WHO);
Legal status
Legal status	US: Not FDA-approved ; OTC (RU);
Identifiers
	IUPAC name N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide;
CAS Number	53783-83-8 ;
PubChem CID	64377;
ChemSpider	57947 ;
UNII	H191JFG8WA;
KEGG	D07199 ;
NIAID ChemDB	007760;
ECHA InfoCard	100.053.409
Chemical and physical data
Formula	C16H28N2O2
Molar mass	280.406 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C;
	InChI InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19) ; Key:UXQDWARBDDDTKG-UHFFFAOYSA-N ;
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Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.^[1]^[2]

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.^[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References

↑ Ostheimer, K. E.; Busch, T.; Görtelmeyer, R.; Hahn, K. D. (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. ISSN 0004-4172. PMID 2686658.
↑ Diezel, W.; Michel, G.; Görtelmeyer, R.; Ostheimer, K. E. (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. ISSN 0004-4172. PMID 8494582.
↑ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.

External links

Viru-Merz website

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[1] Ostheimer, K. E.; Busch, T.; Görtelmeyer, R.; Hahn, K. D. (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. ISSN 0004-4172. PMID 2686658.

[2] Diezel, W.; Michel, G.; Görtelmeyer, R.; Ostheimer, K. E. (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. ISSN 0004-4172. PMID 8494582.

[pmid6297383-3] Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.