Myelin-associated glycoprotein

myelin associated glycoprotein
Identifiers
Symbol	MAG
Alt. symbols	GMA
Entrez	4099
HUGO	6783
OMIM	159460
RefSeq	NM_080600
UniProt	P20916
Other data
Locus	Chr. 19 q13.1

MAG
Identifiers
Aliases	MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDs	OMIM: 159460 MGI: 96912 HomoloGene: 1771 GeneCards: MAG
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	35,313,804 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	30,914,873 bp[2]
Gene ontology
Molecular function	• receptor binding; • lipid binding; • protein kinase binding; • carbohydrate binding; • sialic acid binding; • protein homodimerization activity; • ganglioside GT1b binding;
Cellular component	• cytoplasm; • plasma membrane; • integral component of plasma membrane; • membrane; • integral component of membrane; • paranode region of axon; • myelin sheath adaxonal region; • myelin; • compact myelin; • Schmidt-Lanterman incisure; • membrane raft; • mesaxon;
Biological process	• cell adhesion; • nervous system development; • negative regulation of neuron projection development; • substantia nigra development; • central nervous system myelination; • negative regulation of axon extension; • positive regulation of myelination; • negative regulation of neuron apoptotic process; • negative regulation of neuron differentiation; • positive regulation of astrocyte differentiation; • negative regulation of axonogenesis; • leukocyte migration; • cellular response to mechanical stimulus; • cell-cell adhesion via plasma-membrane adhesion molecules; • transmission of nerve impulse; • axon regeneration;
	Sources:Amigo / QuickGO
Orthologs
	4099
	17136
	ENSG00000105695
	ENSMUSG00000036634
	P20916
	P20917
	NM_080600; NM_001199216; NM_002361
NM_010758; NM_001346084; NM_001346085; NM_001346086; NM_001346087;
	NM_001346088; NM_001346089
	NP_001186145; NP_002352; NP_542167
NP_001333013; NP_001333014; NP_001333015; NP_001333016; NP_001333017;
	NP_001333018; NP_034888
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NoGo-66 receptor, (NgR).^[5] MAG is believed to be involved in myelination during nerve regeneration.^[6]

External links

Myelin-associated+glycoprotein at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105695 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036634 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126.
↑ Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105695 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036634 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126.

[6] Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.

Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

Myelin-associated glycoprotein

See also

External links

References