PMP2

PMP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPMP2, FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein
External IDsMGI: 102667 HomoloGene: 20589 GeneCards: PMP2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.13Start81,440,326 bp[1]
End81,447,523 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5375

18857

Ensembl

ENSG00000147588

ENSMUSG00000052468

UniProt

P02689

P24526

RefSeq (mRNA)

NM_002677
NM_001348381

NM_001030305

RefSeq (protein)

NP_002668
NP_001335310

NP_001025476

Location (UCSC)Chr 8: 81.44 – 81.45 MbChr 3: 10.18 – 10.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene.[5][6][7] Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins (FABPs).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147588 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052468 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K (Jan 1992). "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin". Biochem Biophys Res Commun. 181 (1): 204–7. doi:10.1016/S0006-291X(05)81402-0. PMID 1720307.
  6. ↑ Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N (Feb 1994). "Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)". Genomics. 18 (2): 244–8. doi:10.1006/geno.1993.1462. PMID 8288226.
  7. ↑ "Entrez Gene: PMP2 peripheral myelin protein 2".

Further reading

  • Narayanan V, Barbosa E, Reed R, Tennekoon G (1988). "Characterization of a cloned cDNA encoding rabbit myelin P2 protein". J. Biol. Chem. 263 (17): 8332–7. PMID 2453513.
  • Jones TA, Bergfors T, Sedzik J, Unge T (1988). "The three-dimensional structure of P2 myelin protein". EMBO J. 7 (6): 1597–604. PMC 457142. PMID 2458918.
  • Ishaque A, Hofmann T, Eylar EH (1982). "The complete amino acid sequence of the rabbit P2 protein". J. Biol. Chem. 257 (2): 592–5. PMID 6172423.
  • Suzuki M, Kitamura K, Sakamoto Y, Uyemura K (1983). "The complete amino acid sequence of human P2 protein". J. Neurochem. 39 (6): 1759–62. doi:10.1111/j.1471-4159.1982.tb08017.x. PMID 6183401.
  • Trapp BD, Dubois-Dalcq M, Quarles RH (1984). "Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells". J. Neurochem. 43 (4): 944–8. doi:10.1111/j.1471-4159.1984.tb12828.x. PMID 6206203.
  • Narayanan V, Ripepi B, Jabs EW, et al. (1994). "Partial structure and mapping of the human myelin P2 protein gene". J. Neurochem. 63 (6): 2010–3. doi:10.1046/j.1471-4159.1994.63062010.x. PMID 7525873.
  • Besançon R, Latour P, Lara K, et al. (2001). "Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2)". Hum. Mutat. 17 (3): 237. doi:10.1002/humu.11. PMID 11241848.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.