TSPAN2

TSPAN2
Identifiers
AliasesTSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDsMGI: 1917997 HomoloGene: 21169 GeneCards: TSPAN2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p13.2Start115,048,011 bp[1]
End115,089,500 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10100

70747

Ensembl

ENSG00000134198

ENSMUSG00000027858

UniProt

O60636

Q922J6

RefSeq (mRNA)

NM_001308315
NM_001308316
NM_005725

NM_001243132
NM_027533

RefSeq (protein)

NP_001295244
NP_001295245
NP_005716

NP_001230061
NP_081809

Location (UCSC)Chr 1: 115.05 – 115.09 MbChr 3: 102.73 – 102.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.[5][6][7]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134198 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027858 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
  6. ↑ Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
  7. 1 2 "Entrez Gene: TSPAN2 tetraspanin 2".

Further reading

  • Hemler ME (2002). "Specific tetraspanin functions". J. Cell Biol. 155 (7): 1103–7. doi:10.1083/jcb.200108061. PMC 2199333. PMID 11756464.
  • Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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