| City | Country (Subdivision) | IATA | Airport | Notes |
| Birmingham | United States (Alabama) | BHM | Birmingham-Shuttlesworth International Airport | |
| Huntsville | United States (Alabama) | HSV | Huntsville International Airport | |
| Mobile | United States (Alabama) | MOB | Mobile Regional Airport | |
| Phoenix | United States (Arizona) | PHX | Sky Harbor International Airport | |
| Fayetteville | United States (Arkansas) | XNA | Northwest Arkansas Regional Airport | |
| Little Rock | United States (Arkansas) | LIT | Little Rock National Airport | |
| Los Angeles | United States (California) | LAX | Los Angeles International Airport | |
| Colorado Springs | United States (Colorado) | COS | Colorado Springs Airport | |
| Denver | United States (Colorado) | DEN | Denver International Airport | Hub |
| Durango | United States (Colorado) | DRO | Durango-La Plata County Airport | |
| Grand Junction | United States (Colorado) | GJT | Grand Junction Regional Airport | |
| Gunnison | United States (Colorado) | GUC | Gunnison-Crested Butte Regional Airport | Seasonal Service |
| Montrose/Telluride | United States (Colorado) | MTJ | Montrose Regional Airport | |
| Hartford | United States (Connecticut) | BDL | Bradley International Airport | |
| Fort Walton Beach | United States (Florida) | VPS | Destin–Fort Walton Beach Airport | |
| Jacksonville | United States (Florida) | JAX | Jacksonville International Airport | |
| Panama City | United States (Florida) | ECP | Northwest Florida Beaches International Airport | |
| Pensacola | United States (Florida) | PNS | Pensacola Regional Airport | |
| Sarasota/Bradenton | United States (Florida) | SRQ | Sarasota-Bradenton International Airport | |
| Atlanta | United States (Georgia) | ATL | Hartsfield-Jackson Atlanta International Airport | |
| Savannah | United States (Georgia) | SAV | Savannah/Hilton Head International Airport | |
| Chicago | United States (Illinois) | ORD | O'Hare International Airport | Hub |
| Moline | United States (Illinois) | MLI | Quad City International Airport | |
| Peoria | United States (Illinois) | PIA | General Wayne A. Downing Peoria International Airport | |
| Evansville | United States (Indiana) | EVV | Evansville Regional Airport | |
| Indianapolis | United States (Indiana) | IND | Indianapolis International Airport | |
| South Bend | United States (Indiana) | SBN | South Bend International Airport | |
| Cedar Rapids | United States (Iowa) | CID | The Eastern Iowa Airport | |
| Des Moines | United States (Iowa) | DSM | Des Moines International Airport | |
| Wichita | United States (Kansas) | ICT | Wichita Eisenhower National Airport | |
| Cincinnati, Ohio area | United States (Kentucky) | CVG | Cincinnati/Northern Kentucky International Airport | Cincinnati is in Ohio, airport is in Kentucky |
| Lexington | United States (Kentucky) | LEX | Blue Grass Airport | |
| Louisville | United States (Kentucky) | SDF | Louisville International Airport | |
| Alexandria | United States (Louisiana) | AEX | Alexandria International Airport | |
| Baton Rouge | United States (Louisiana) | BTR | Baton Rouge Metropolitan Airport | |
| Lafayette | United States (Louisiana) | LFT | Lafayette Regional Airport | |
| Lake Charles | United States (Louisiana) | LCH | Lake Charles Regional Airport | |
| New Orleans | United States (Louisiana) | MSY | Louis Armstrong New Orleans International Airport | |
| Monroe | United States (Louisiana) | MLU | Monroe Regional Airport | |
| Shreveport | United States (Louisiana) | SHV | Shreveport Regional Airport | |
| Portland | United States (Maine) | PWM | Portland International Jetport | |
| Baltimore | United States (Maryland) | BWI | Baltimore/Washington International Airport | |
| Boston | United States (Massachusetts) | BOS | Logan International Airport | |
| Detroit | United States (Michigan) | DTW | Detroit Metropolitan Wayne County Airport | |
| Grand Rapids | United States (Michigan) | GRR | Gerald R. Ford International Airport | |
| Flint | United States (Michigan) | FNT | Bishop International Airport | |
| Lansing | United States (Michigan) | LAN | Capital Region International Airport | |
| Traverse City | United States (Michigan) | TVC | Cherry Capital Airport | |
| Minneapolis/St. Paul | United States (Minnesota) | MSP | Minneapolis-Saint Paul International Airport | |
| Columbus | United States (Mississippi) | GTR | Golden Triangle Regional Airport | |
| Gulfport/Biloxi | United States (Mississippi) | GPT | Gulfport-Biloxi International Airport | |
| Jackson | United States (Mississippi) | JAN | Jackson-Evers International Airport | |
| Kansas City | United States (Missouri) | MCI | Kansas City International Airport | |
| St. Louis | United States (Missouri) | STL | Lambert-Saint Louis International Airport | |
| Springfield | United States (Missouri) | SGF | Springfield-Branson National Airport | |
| Billings | United States (Montana) | BIL | Billings Logan International Airport | |
| Lincoln | United States (Nebraska) | LNK | Lincoln Airport | |
| Omaha | United States (Nebraska) | OMA | Eppley Airfield | |
| Manchester | United States (New Hampshire) | MHT | Manchester-Boston Regional Airport | |
| Newark | United States (New Jersey) | EWR | Newark Liberty International Airport | Hub |
| Atlantic City | United States (New Jersey) | ACY | Atlantic City International Airport | |
| Albuquerque | United States (New Mexico) | ABQ | Albuquerque International Sunport | |
| Hobbs | United States (New Mexico) | HOB | Lea County Regional Airport | |
| Albany | United States (New York) | ALB | Albany International Airport | |
| Buffalo | United States (New York) | BUF | Buffalo Niagara International Airport | |
| New York City | United States (New York) | LGA | LaGuardia Airport | |
| Rochester | United States (New York) | ROC | Greater Rochester International Airport | |
| Syracuse | United States (New York) | SYR | Syracuse Hancock International Airport | |
| Asheville | United States (North Carolina) | AVL | Asheville Regional Airport | |
| Charlotte | United States (North Carolina) | CLT | Charlotte/Douglas International Airport | |
| Greensboro | United States (North Carolina) | GSO | Piedmont Triad International Airport | |
| Raleigh/Durham | United States (North Carolina) | RDU | Raleigh-Durham International Airport | |
| Fargo | United States (North Dakota) | FAR | Hector International Airport | |
| Williston | United States (North Dakota) | ISN | Sloulin Field International Airport | |
| Dickinson | United States (North Dakota) | DIK | Dickinson Theodore Roosevelt Regional Airport | |
| Bismarck | United States (North Dakota) | BIS | Bismarck Municipal Airport | |
| Minot | United States (North Dakota) | MOT | Minot International Airport | |
| Akron | United States (Ohio) | CAK | Akron-Canton Regional Airport | |
| Cleveland | United States (Ohio) | CLE | Hopkins International Airport | Hub |
| Columbus | United States (Ohio) | CMH | John Glenn Columbus International Airport | |
| Dayton | United States (Ohio) | DAY | Dayton International Airport | |
| Oklahoma City | United States (Oklahoma) | OKC | Will Rogers World Airport | |
| Tulsa | United States (Oklahoma) | TUL | Tulsa International Airport | |
| Allentown | United States (Pennsylvania) | ABE | Lehigh Valley International Airport | |
| Erie | United States (Pennsylvania) | ERI | Erie International Airport | |
| Harrisburg | United States (Pennsylvania) | MDT | Harrisburg International Airport | |
| Philadelphia | United States (Pennsylvania) | PHL | Philadelphia International Airport | |
| Pittsburgh | United States (Pennsylvania) | PIT | Pittsburgh International Airport | |
| State College | United States (Pennsylvania) | SCE | University Park Airport | |
| Wilkes-Barre | United States (Pennsylvania) | AVP | Wilkes-Barre/Scranton International Airport | |
| Providence | United States (Rhode Island) | PVD | T. F. Green Airport | |
| Charleston | United States (South Carolina) | CHS | Charleston International Airport | |
| Columbia | United States (South Carolina) | CAE | Columbia Metropolitan Airport | |
| Greenville/Spartanburg | United States (South Carolina) | GSP | Greenville-Spartanburg International Airport | |
| Myrtle Beach | United States (South Carolina) | MYR | Myrtle Beach International Airport | |
| Rapid City | United States (South Dakota) | RAP | Rapid City Regional Airport | |
| Sioux Falls | United States (South Dakota) | FSD | Sioux Falls Regional Airport | |
| Knoxville | United States (Tennessee) | TYS | McGhee Tyson Airport | |
| Memphis | United States (Tennessee) | MEM | Memphis International Airport | |
| Nashville | United States (Tennessee) | BNA | Nashville International Airport | |
| Amarillo | United States (Texas) | AMA | Rick Husband Amarillo International Airport | |
| Austin | United States (Texas) | AUS | Austin-Bergstrom International Airport | |
| Brownsville | United States (Texas) | BRO | Brownsville/South Padre Island International Airport | |
| College Station | United States (Texas) | CLL | Easterwood Airport | |
| Corpus Christi | United States (Texas) | CRP | Corpus Christi International Airport | |
| Dallas–Fort Worth | United States (Texas) | DFW | Dallas/Fort Worth International Airport | |
| Del Rio | United States (Texas) | DRT | Del Rio International Airport | |
| El Paso | United States (Texas) | ELP | El Paso International Airport | |
| Fort Hood | United States (Texas) | GRK | Killeen-Fort Hood Regional Airport | |
| Harlingen | United States (Texas) | HRL | Valley International Airport | |
| Houston | United States (Texas) | IAH | George Bush Intercontinental Airport | Hub |
| Laredo | United States (Texas) | LRD | Laredo International Airport | |
| Lubbock | United States (Texas) | LBB | Lubbock Preston Smith International Airport | |
| McAllen | United States (Texas) | MFE | McAllen-Miller International Airport | |
| Midland | United States (Texas) | MAF | Midland International Airport | |
| San Antonio | United States (Texas) | SAT | San Antonio International Airport | |
| Tyler | United States (Texas) | TYR | Tyler Pounds Regional Airport | |
| Waco | United States (Texas) | ACT | Waco Regional Airport | |
| Burlington | United States (Vermont) | BTV | Burlington International Airport | |
| Norfolk | United States (Virginia) | ORF | Norfolk International Airport | |
| Richmond | United States (Virginia) | RIC | Richmond International Airport | |
| Roanoke | United States (Virginia) | ROA | Roanoke Regional Airport | |
| Washington, D.C. area | United States (Virginia) | DCA | Ronald Reagan Washington National Airport | |
| Washington, D.C. area | United States (Virginia) | IAD | Washington Dulles International Airport | Hub |
| Charleston | United States (West Virginia) | CRW | Yeager Airport | |
| Appleton | United States (Wisconsin) | ATW | Appleton International Airport | |
| Green Bay | United States (Wisconsin) | GRB | Austin Straubel International Airport | |
| Madison | United States (Wisconsin) | MSN | Dane County Regional Airport | |
| Milwaukee | United States (Wisconsin) | MKE | General Mitchell International Airport | |
| Wausau | United States (Wisconsin) | CWA | Central Wisconsin Airport | |
| Halifax | Canada | YHZ | Halifax International Airport | |
| Kelowna | Canada | YLW | Kelowna International Airport |
| Montréal | Canada | YUL | Montréal-Pierre Elliott Trudeau International Airport | |
| Ottawa | Canada | YOW | Ottawa Macdonald-Cartier International Airport | |
| Quebec City | Canada | YQB | Québec/Jean Lesage International Airport | |
| Toronto | Canada | YYZ | Toronto Pearson International Airport | |
| Winnipeg | Canada | YWG | Winnipeg James Armstrong Richardson International Airport |
|
| Acapulco | Mexico | ACA | General Juan N. Álvarez International Airport |
|
| Aguascalientes | Mexico | AGU | Lic. Jesús Terán Peredo International Airport |
|
| Chihuahua | Mexico | CUU | Roberto Fierro Villalobos International Airport |
|
| Ciudad del Carmen | Mexico | CME | Ciudad del Carmen International Airport |
|
| Durango | Mexico | DGO | General Guadalupe Victoria International Airport |
|
| Guadalajara | Mexico | GDL | Don Miguel Hidalgo y Costilla International Airport |
|
| Huatulco | Mexico | HUX | Bahías de Huatulco International Airport |
|
| Ixtapa-Zihuatanejo | Mexico | ZIH | Ixtapa-Zihuatanejo International Airport |
|
| León | Mexico | BJX | Del Bajío International Airport |
|
| Manzanillo | Mexico | ZLO | Playa de Oro International Airport |
|
| Mazatlán | Mexico | MZT | General Rafael Buelna International Airport |
|
| Mexico City | Mexico | MEX | Mexico City International Airport |
|
| Monterrey | Mexico | MTY | General Mariano Escobedo International Airport |
|
| Morelia | Mexico | MLM | General Francisco J. Mujica International Airport |
|
| Oaxaca | Mexico | OAX | Xoxocotlán International Airport |
|
| Puebla City | Mexico | PBC | Hermanos Serdán International Airport |
|
| Puerto Vallarta | Mexico | PVR | Lic. Gustavo Díaz Ordaz International Airport |
|
| Saltillo | Mexico | SLW | Plan de Guadalupe International Airport |
|
| San José del Cabo | Mexico | SJD | Los Cabos International Airport |
|
| San Luis Potosí | Mexico | SLP | Ponciano Arriaga International Airport |
|
| Querétaro | Mexico | QRO | Querétaro International Airport |
|
| Tampico | Mexico | TAM | General Francisco Javier Mina International Airport |
|
| Toluca | Mexico | TLC | Lic. Adolfo López Mateos International Airport |
|
| Torreón | Mexico | TRC | Francisco Sarabia International Airport |
|
| Tuxtla Gutierrez | Mexico | TGZ | Angel Albino Corzo International Airport |
|
| Veracruz | Mexico | VER | General Heriberto Jara International Airport |
|
| Villahermosa | Mexico | VSA | Carlos Rovirosa Pérez International Airport |
|