Tutin (toxin)

Tutin
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
ECHA InfoCard 100.236.780 Edit this at Wikidata
Chemical and physical data
Formula C15H18O6
Molar mass 294.299 g/mol
3D model (JSmol)
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Tutin is a poisonous plant derivative found in New Zealand tutu plants (several species in the Coriaria genus). It acts as a potent antagonist of the glycine receptor,[1] and has powerful convulsant effects.[2] It is used in scientific research into the glycine receptor. It is sometimes associated with outbreaks of toxic honey poisoning when bees feed on honeydew exudate from the sap-sucking passionvine hopper (Scolypopa australis) insect, when the vine hoppers have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passionvine hoppers feeding on tutu plants.[3]

References

  1. ↑ Fuentealba J, Guzmán L, Manríquez-Navarro P, Pérez C, Silva M, Becerra J, Aguayo LG. Inhibitory effects of tutin on glycine receptors in spinal neurons. European Journal of Pharmacology. 2007 Mar 15;559(1):61-4. PMID 17303114
  2. ↑ Zhou H, Tang YH, Zheng Y. A new rat model of acute seizures induced by tutin. Brain Research. 2006 May 30;1092(1):207-13. PMID 16674929
  3. ↑ Background on toxic honey. New Zealand Food Safety Authority.


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