Methyl fluoroacetate

Methyl fluoroacetate
Names
Other names
MFA
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.006.563
EC Number 207-218-7
UNII
Properties
C3H5FO2
Molar mass 92.07 g·mol−1
Appearance Colorless liquid
Melting point −40 °C (−40 °F; 233 K)
Boiling point 104 °C (219 °F; 377 K)
Hazards
Main hazards Extremely toxic
GHS pictograms
GHS signal word Danger
H226, H300, H315, H319, H335, H400
P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P273, P280, P301+310, P302+352, P303+361+353, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P370+378, P391
Flash point −32 °C (−26 °F; 241 K)
Lethal dose or concentration (LD, LC):
6 mg/kg (mice)
Related compounds
Related compounds
 Fluoroacetic acid
Sodium fluoroacetate
Fluoroacetamide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Methyl fluoroacetate (MFA) is an extremely toxic methyl ester of fluoroacetic acid. It is a colorless, odorless liquid at room temperature. Because of its extreme toxicity, MFA was studied for potential use as chemical weapon.[1]

Synthesis

MFA was first synthesized in 1896 by reacting methyl iodoacetate with silver fluoride. It can also be synthesized by reacting methyl chloroacetate with potassium fluoride[1]

Toxicity

MFA is a convulsant poison. It causes severe convulsions in poisoned victims.[2] Death results from respiratory failure.[3]

See also

References

  1. 1 2 Gribble, Gordon W. (July 1973). "Fluoroacetate toxicity" (PDF). Journal of Chemical Education. 50 (7): 460–2. doi:10.1021/ed050p460. PMID 4711243.
  2. ↑ Saunders, B. C.; Stacey, G. J. (1948). "358. Toxic fluorine compounds containing the C–F link. Part I. Methyl Fluoroacetate and Related Compounds". J. Chem. Soc. 0: 1773–1779. doi:10.1039/jr9480001773.
  3. ↑ FOSS, G. L. (June 1948). "THE TOXICOLOGY AND PHARMACOLOGY OF METHYL FLUOROACETATE (MFA) IN ANIMALS, WITH SOME NOTES ON EXPERIMENTAL THERAPY". British Journal of Pharmacology and Chemotherapy. 3 (2): 118–127. doi:10.1111/j.1476-5381.1948.tb00362.x. PMC 1509813. PMID 18866990.
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