FG-7142

FG-7142
Names
IUPAC name
N-Methyl-9H-pyrido[5,4-b]indole-3-carboxamide
Other names
ZK-31906
Identifiers
3D model (JSmol)
ChemSpider
MeSH C526324
UNII
Properties
C13H11N3O
Molar mass 225.24594
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

FG-7142 (ZK-31906) is a drug which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor.[1] It has anorectic,[2] anxiogenic and pro-convulsant effects.[3] It also increases release of acetylcholine and noradrenaline,[4] and improves memory retention in animal studies.[5]

References

  1. ↑ Stevenson CW, Halliday DM, Marsden CA, Mason R (2007). "Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions". Synapse. 61 (8): 646–63. doi:10.1002/syn.20414. PMID 17503486.
  2. ↑ Cottone P, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology. 2007 May;32(5):1069-81. PMID 17077811
  3. ↑ Evans AK, Lowry CA. Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. CNS Drug Reviews. 2007 Winter;13(4):475-501. PMID 18078430
  4. ↑ Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R. Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat. Neuroscience. 2006 Sep 1;141(3):1481-8. PMID 16781820
  5. ↑ McNally GP, Augustyn KA, Richardson R. GABA(A) receptors determine the temporal dynamics of memory retention. Learning and Memory. 2008 Feb 19;15(3):106-11. PMID 18285469
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