IPTBO

IPTBO
Names
IUPAC name
4-Isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide
Other names
4-Isopropylbicyclophosphate
Identifiers
3D model (JSmol)
Properties
C7H13O4P
Molar mass 192.15 g·mol−1
Hazards
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
180 μg/kg (mice)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

IPTBO (isopropylbicyclophosphate) is a bicyclic phosphate convulsant.[2] It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice.[3][4]

See also

References

  1. ↑ Milbrath, Dean S.; Engel, Judith L.; Verkade, John G.; Casida, John E. (February 1979). "Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes". Toxicology and Applied Pharmacology. 47 (2): 287–293. doi:10.1016/0041-008x(79)90323-5. PMID 452023.
  2. ↑ Mattsson, Hillevi (1980). "Bicyclic phosphates increase the cyclic GMP level in rat cerebellum, presumably due to reduced GABA inhibition". Brain Research. 181 (1): 175–84. doi:10.1016/0006-8993(80)91267-6. PMID 6243222.
  3. ↑ Mattsson, Hillevi (1980). "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO)". Brain Research. 181 (1): 175–84. doi:10.1016/0006-8993(80)91267-6. PMID 6243222.
  4. ↑ Blenkinsop, I.S; Coult, D.B; Davies, W.E; Howells, D.J (1984). "Effects of dose and time after administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo (2,2,2)octane-1-oxide (IPTBO) on cyclic nucleotide concentrations in mouse cerebellum". Neurochemistry International. 6 (4): 453. doi:10.1016/0197-0186(84)90114-1. PMID 20488068.


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