Troponin T

Troponin

Troponin T is a part of the troponin complex expressed in skeletal and cardiac myocytes. The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. Especially the cardiac subtype of troponin T is useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs. [1] Troponin T is part of the troponin complex where it binds to tropomyosin and helps position it on actin[2], and, together with the rest of the troponin complex, modulates contraction of striated muscle.[3]

The tissue-specific subtypes are:

Increased troponin T levels after an episode of chest pain indicates myocardial infarction.[4]

Reference values

The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL.[5]

History

Troponin T was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay.[6]

In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).[7][8]

References

  1. ↑ Braunwald's Heart Disease. Elsevier Saunders. p. 433. ISBN 978-1-4557-5134-1.
  2. ↑ marieb, elaine (2004)
  3. ↑ black, joyce (2005)
  4. ↑ Michael A. Chen. "Troponin test". MedlinePlus, U.S. National Library of Medicine. Retrieved 2017-07-24. Review Date 10/6/2015
  5. ↑ Ashvarya Mangla. "Troponins". medscape. Retrieved 2017-07-24. Updated: Jan 14, 2015
  6. ↑ "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. 2008. Retrieved 2010-05-01.
  7. ↑ "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 2009. Retrieved 2012-04-04.
  8. ↑ "Health Conditions: Diseases, conditions & medical information - MSN Health & Fitness". healthyliving.msn.com. Retrieved 12 April 2018.

See also

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