MYH2

MYH2
Identifiers
AliasesMYH2, IBM3, MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa, MYPOP, myosin, heavy chain 2, skeletal muscle, adult, myosin heavy chain 2
External IDsMGI: 1339710 HomoloGene: 23019 GeneCards: MYH2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start10,521,148 bp[1]
End10,549,957 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4620

17882

Ensembl

ENSG00000125414

ENSMUSG00000033196

UniProt

Q9UKX2

G3UW82

RefSeq (mRNA)

NM_017534
NM_001100112

NM_001039545
NM_144961

RefSeq (protein)

NP_001093582
NP_060004

NP_001034634

Location (UCSC)Chr 17: 10.52 – 10.55 MbChr 11: 67.17 – 67.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-2 is a protein that in humans is encoded by the MYH2 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125414 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033196 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.
  6. ↑ "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

Further reading

  • Schwartz CE, McNally E, Leinwand L, Skolnick MH (1987). "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13". Cytogenet. Cell Genet. 43 (1–2): 117–20. doi:10.1159/000132307. PMID 2877813.
  • Ennion S, Sant'ana Pereira J, Sargeant AJ, et al. (1995). "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express". J. Muscle Res. Cell. Motil. 16 (1): 35–43. doi:10.1007/BF00125308. PMID 7751403.
  • Hisatome I, Morisaki T, Kamma H, et al. (1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870–81. PMID 9730972.
  • Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
  • Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
  • Onuoha GN, Alpar EK, Laprade M, et al. (1999). "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle". Clinical and investigative medicine. Médecine clinique et experimentale. 22 (5): 180–4. PMID 10579056.
  • Martinsson T, Oldfors A, Darin N, et al. (2001). "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614–9. doi:10.1073/pnas.250289597. PMC 18967. PMID 11114175.
  • Tajsharghi H, Thornell LE, Darin N, et al. (2002). "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age". Neurology. 58 (5): 780–6. doi:10.1212/wnl.58.5.780. PMID 11889243.
  • England K, Ashford D, Kidd D, Rumsby M (2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. PMID 11897493.
  • Allen DL, Leinwand LA (2003). "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter". J. Biol. Chem. 277 (47): 45323–30. doi:10.1074/jbc.M208302200. PMID 12235157.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim EJ, Helfman DM (2003). "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem. 278 (32): 30063–73. doi:10.1074/jbc.M304909200. PMID 12756252.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chung MC, Kawamoto S (2005). "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation". J. Biol. Chem. 279 (53): 56042–52. doi:10.1074/jbc.M404791200. PMID 15496418.
  • Tajsharghi H, Darin N, Rekabdar E, et al. (2005). "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)". Eur. J. Hum. Genet. 13 (5): 617–22. doi:10.1038/sj.ejhg.5201375. PMID 15741996.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Li M, Lionikas A, Yu F, et al. (2006). "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)". Neuromuscul. Disord. 16 (11): 782–91. doi:10.1016/j.nmd.2006.07.023. PMC 1693964. PMID 17005402.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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