Tropomodulin 4

TMOD4
Identifiers
AliasesTMOD4, SK-TMOD, tropomodulin 4
External IDsMGI: 1355285 HomoloGene: 8355 GeneCards: TMOD4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start151,169,986 bp[1]
End151,176,284 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

29765

50874

Ensembl

ENSG00000163157

ENSMUSG00000005628

UniProt

Q9NZQ9

Q9JLH8

RefSeq (mRNA)

NM_013353

NM_016712

RefSeq (protein)

NP_037485

NP_057921

Location (UCSC)Chr 1: 151.17 – 151.18 MbChr 3: 95.12 – 95.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.[5][6]

Function

This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163157 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005628 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
  6. ↑ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.
  7. ↑ "Entrez Gene: TMOD4, Tropomodulin 4 (muscle)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cox PR, Siddique T, Zoghbi HY (2001). "Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4". BMC Genomics. 2: 7. doi:10.1186/1471-2164-2-7. PMC 59888. PMID 11716785.
  • McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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