MYO3A

MYO3A
Identifiers
Aliases	MYO3A, DFNB30, myosin IIIA
External IDs	MGI: 2183924 HomoloGene: 49486 GeneCards: MYO3A
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	26,212,536 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	22,618,252 bp[2]
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • actin-dependent ATPase activity; • ADP binding; • calmodulin binding; • kinase activity; • microfilament motor activity; • protein serine/threonine kinase activity; • plus-end directed microfilament motor activity; • actin binding; • motor activity; • ATP binding; • protein binding;
Cellular component	• filamentous actin; • filopodium; • cytoskeleton; • myosin complex; • cytoplasm; • stereocilium tip; • stereocilium; • filopodium tip; • cell projection;
Biological process	• phosphorylation; • response to stimulus; • protein phosphorylation; • protein autophosphorylation; • visual perception; • sensory perception of sound; • cochlea morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	53904
	667663
	ENSG00000095777
	ENSMUSG00000025716
	Q8NEV4
	Q8K3H5
	NM_017433
	NM_148413
	NP_059129
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin IIIA is a protein that in humans is encoded by the MYO3A gene.^[5]^[6]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000095777 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025716 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dose AC, Burnside B (Sep 2000). "Cloning and chromosomal localization of a human class III myosin". Genomics. 67 (3): 333–42. doi:10.1006/geno.2000.6256. PMID 10936054.
1 2 "Entrez Gene: MYO3A myosin IIIA".

Walsh T, Walsh V, Vreugde S, et al. (2002). "From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7518–23. doi:10.1073/pnas.102091699. PMC 124268. PMID 12032315.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Komaba S, Inoue A, Maruta S, et al. (2003). "Determination of human myosin III as a motor protein having a protein kinase activity". J. Biol. Chem. 278 (24): 21352–60. doi:10.1074/jbc.M300757200. PMID 12672820.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Kambara T, Komaba S, Ikebe M (2007). "Human myosin III is a motor having an extremely high affinity for actin". J. Biol. Chem. 281 (49): 37291–301. doi:10.1074/jbc.M603823200. PMID 17012748.
Schneider ME, Dosé AC, Salles FT, et al. (2006). "A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression". J. Neurosci. 26 (40): 10243–52. doi:10.1523/JNEUROSCI.2812-06.2006. PMID 17021180.
Dosé AC, Ananthanarayanan S, Moore JE, et al. (2007). "Kinetic mechanism of human myosin IIIA". J. Biol. Chem. 282 (1): 216–31. doi:10.1074/jbc.M605964200. PMID 17074769.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000095777 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025716 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10936054-5] Dose AC, Burnside B (Sep 2000). "Cloning and chromosomal localization of a human class III myosin". Genomics. 67 (3): 333–42. doi:10.1006/geno.2000.6256. PMID 10936054.

[entrez-6] 1 2 "Entrez Gene: MYO3A myosin IIIA".

MYO3A

References

Further reading