MYL6B

MYL6B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYL6B, MLC1SA, myosin light chain 6B
External IDsMGI: 1917789 HomoloGene: 86887 GeneCards: MYL6B
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.2Start56,152,256 bp[1]
End56,159,647 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

140465

216459

Ensembl

ENSG00000196465

ENSMUSG00000039824

UniProt

P14649

Q8CI43

RefSeq (mRNA)

NM_002475
NM_001199629

NM_172259

RefSeq (protein)

NP_001186558
NP_002466

NP_758463

Location (UCSC)Chr 12: 56.15 – 56.16 MbChr 10: 128.49 – 128.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.[5][6][7]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196465 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039824 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res. 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161.
  6. ↑ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. PMC 360973. PMID 2304459.
  7. 1 2 "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle".

Further reading

  • Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. PMID 8856505.
  • Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.


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