Dimetindene

Dimetindene

Clinical data
Trade names	Fenistil
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	D04AA13 (WHO) R06AB03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)
Identifiers
IUPAC name N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number	5636-83-9 Y 3614-69-5
PubChem CID	21855
DrugBank	DB08801 Y
ChemSpider	20541 Y
UNII	661FH77Z3P
KEGG	D07853 Y
ChEMBL	CHEMBL22108 Y
ECHA InfoCard	100.024.622
Chemical and physical data
Formula	C20H24N2
Molar mass	292.418 g/mol
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 Y Key:MVMQESMQSYOVGV-UHFFFAOYSA-N Y
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Dimetindene^[1] (trade name Fenistil; other name dimethindene maleate) is an antiallergic drug. Dimetindene is an antihistamine/anticholinergic that is a selective H1 antagonist.^[2] As dimetindene only minimally passes across the blood-brain barrier,^[3] it is classified as a second generation antihistamine.

Clinical use

Dimetindene is used orally and topically as an antipruritic.^[4] It is used topically to treat skin irritations, such as insect bites. Dimentidene is also administered orally to treat allergies, such as hay fever. Unlike first generation antihistamines, it causes only minimal drowsiness.

References