Octatropine methylbromide

Octatropine methylbromide
Clinical data
Synonyms 8-Methyltropinium bromide 2- propylvalerate
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		 Oral
    ATC code
    • none
    Pharmacokinetic data
    Bioavailability 10 to 25% (oral)
    Protein binding Unknown
    Metabolism Hepatic
    Elimination half-life Unknown
    Identifiers
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    ChEMBL
    ECHA InfoCard 100.001.169 Edit this at Wikidata
    Chemical and physical data
    Formula C17H32BrNO2
    Molar mass 362.345 g/mol
    3D model (JSmol)
     ☒N☑Y (what is this?)  (verify)

    Octatropine methylbromide (INN) or anisotropine methylbromide (USAN), trade names Valpin, Endovalpin, Lytispasm and others,[1] is a muscarinic antagonist and antispasmodic. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of peptic ulcer,[2] and promoted as being more specific to the gastrointestinal tract than other anticholinergics, although its selectivity was questioned in later studies.[3][4]

    Octatropine has been superseded by more effective agents in the treatment of peptic ulcer disease, and is no longer used. It is still sold in some countries in combination with other drugs, such as phenobarbital and metamizole.

    References

    1. ↑ David J. Triggle; C. R. Ganellin; F. MacDonald (1997). Dictionary of Pharmacological Agents. 2. Boca Raton: Chapman & Hall/CRC. p. 1467. ISBN 0-412-46630-9. Retrieved on August 31, 2008 through Google Book Search.
    2. ↑ Batterman RC, Mouratoff GJ, Kaufman JE (May 1963). "Anisotropine methylbromide: a new antispasmodic for gastrointestinal disorders". Curr Ther Res Clin Exp. 5: 213–8. PMID 13966843.
    3. ↑ Gyermek, Laszlo (1998). Pharmacology of antimuscarinic agents. Boca Raton: CRC Press. p. 183. ISBN 0-8493-8559-8. Retrieved on August 31, 2008 through Google Book Search.
    4. ↑ Bachrach WH (June 1972). "Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug". Am J Dig Dis. 17 (6): 505–12. doi:10.1007/BF02231205. PMID 4555460.


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