Dexchlorpheniramine

Chlorpheniramine
Clinical data
Trade names Chlor-trimeton
AHFS/Drugs.com Monograph
MedlinePlus a682543
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • AU: S3 (Pharmacist only)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.042.779 Edit this at Wikidata
Chemical and physical data
Formula C16H19ClN2
Molar mass 274.788 g/mol
3D model (JSmol)
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Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.

Pharmacology

Pharmacodynamics

Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 µM for the muscarinic acetylcholine receptors using rat brain tissue.[3]

References

  1. ↑ Theunissen, E. L.; Vermeeren, A.; Ramaekers, J. G. (2006). "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance". British Journal of Clinical Pharmacology. 61 (1): 79–86. doi:10.1111/j.1365-2125.2005.02524.x. PMC 1884990. PMID 16390354.
  2. ↑ Ortíz San Román, L.; Sanavia Morán, E.; Campos Domínguez, M.; Peinador García, M. M. (2013). "Síndrome anticolinérgico por dexclorfeniramina como causa de retención urinaria". Anales de Pediatría. 79 (6): 400–1. doi:10.1016/j.anpedi.2013.02.014. PMID 23680058.
  3. ↑ Yamamura HI, Snyder SH (1974). "Muscarinic cholinergic binding in rat brain". Proc. Natl. Acad. Sci. U.S.A. 71 (5): 1725–9. doi:10.1073/pnas.71.5.1725. PMC 388311. PMID 4151898.
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