Filamin

Filamins are a class of proteins that hold two actin filaments at large angles.^[1] Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 immunoglobulin-like repeat modules of roughly 95 amino acids. There are two hinge regions; between repeats 15-16 and 23-24. Filamin gets cleaved at these hinge regions to generate smaller fragments of the protein.

Filamin proteins include:

References

↑ Murray JT, Campbell DG, Peggie M, Mora A, Alfonso M, Cohen P (December 2004). "Identification of filamin C as a new physiological substrate of PKBα using KESTREL". Biochem. J. 384 (Pt 3): 489–94. doi:10.1042/BJ20041058. PMC 1134134. PMID 15461588.

External links

filamins at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid15461588-1] Murray JT, Campbell DG, Peggie M, Mora A, Alfonso M, Cohen P (December 2004). "Identification of filamin C as a new physiological substrate of PKBα using KESTREL". Biochem. J. 384 (Pt 3): 489–94. doi:10.1042/BJ20041058. PMC 1134134. PMID 15461588.