Nizatidine

Nizatidine
Clinical data
Trade names Axid
AHFS/Drugs.com Monograph
MedlinePlus a694030
License data
Pregnancy
category
    Routes of
    administration    		 Oral
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Bioavailability >70%
    Protein binding 35%
    Metabolism Hepatic
    Elimination half-life 1–2 hours
    Excretion Renal
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    ECHA InfoCard 100.155.683 Edit this at Wikidata
    Chemical and physical data
    Formula C12H21N5O2S2
    Molar mass 331.46 g/mol
    3D model (JSmol)
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    Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. It was developed by Eli Lilly and is marketed under the brand names Tazac and Axid.

    Clinical use

    Nizatidine is used to treat duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD/GORD), and to prevent stress ulcers.[1]

    Adverse effects

    Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches.[1]

    History and development

    Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine. In September 2000, Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals.[2] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA).[3] However, a year later, they sold rights of the Axid Oral Solution (including the issued patent[4] protecting the product) to Braintree Laboratories.[5]

    Nizatidine proved to be the last new histamine H2 receptor antagonist introduced prior to the advent of proton pump inhibitors.

    See also

    • Famotidine (Pepcid) — another popular H2 receptor antagonist

    References

    1. 1 2 3 "Nizatidine". Livertox.nih.gov. Retrieved 2015-10-11.
    2. ↑ Archived May 26, 2008, at the Wayback Machine.
    3. ↑ Archived December 26, 2013, at the Wayback Machine.
    4. ↑ "United States Patent: 6930119". Patft.uspto.gov. Retrieved 2015-10-11.
    5. ↑ Archived August 14, 2007, at the Wayback Machine.
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