RHOBTB2

RHOBTB2
Identifiers
AliasesRHOBTB2, DBC2, Rho related BTB domain containing 2, EIEE64
External IDsMGI: 2180557 HomoloGene: 22873 GeneCards: RHOBTB2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p21.3Start22,987,417 bp[1]
End23,020,199 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23221

246710

Ensembl

ENSG00000008853

ENSMUSG00000022075

UniProt

Q9BYZ6

Q91V93

RefSeq (mRNA)

NM_001160036
NM_001160037
NM_015178

NM_153514

RefSeq (protein)

NP_001153508
NP_001153509
NP_055993

NP_705734

Location (UCSC)Chr 8: 22.99 – 23.02 MbChr 14: 69.78 – 69.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene.[5][6]

RHOBTB2 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000008853 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022075 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
  6. 1 2 "Entrez Gene: RHOBTB2 Rho-related BTB domain containing 2".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Hamaguchi M, Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419.
  • Ramos S, Khademi F, Somesh BP, Rivero F (2003). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse". Gene. 298 (2): 147–57. doi:10.1016/S0378-1119(02)00980-0. PMID 12426103.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Siripurapu V, Meth J, Kobayashi N, Hamaguchi M (2005). "DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways". J. Mol. Biol. 346 (1): 83–9. doi:10.1016/j.jmb.2004.11.043. PMID 15663929.
  • Chang FK, Sato N, Kobayashi-Simorowski N, et al. (2007). "DBC2 is essential for transporting vesicular stomatitis virus glycoprotein". J. Mol. Biol. 364 (3): 302–8. doi:10.1016/j.jmb.2006.09.026. PMC 1713265. PMID 17023000.
  • Yoshihara T, Collado D, Hamaguchi M (2007). "Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function". Biochem. Biophys. Res. Commun. 358 (4): 1076–9. doi:10.1016/j.bbrc.2007.05.037. PMC 1934618. PMID 17517369.
  • Collado D, Yoshihara T, Hamaguchi M (2007). "DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation". Biochem. Biophys. Res. Commun. 360 (3): 600–3. doi:10.1016/j.bbrc.2007.06.127. PMC 1986727. PMID 17617377.
  • Ohadi M, Totonchi M, Maguire P, et al. (2007). "Mutation analysis of the DBC2 gene in sporadic and familial breast cancer". Acta oncologica (Stockholm, Sweden). 46 (6): 770–2. doi:10.1080/02841860601047752. PMID 17653899.


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