Interleukin-7 receptor-α

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.[4][5]

IL7R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDsOMIM: 146661 MGI: 96562 HomoloGene: 1646 GeneCards: IL7R
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p13.2Start35,852,695 bp[1]
End35,879,603 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3575

16197

Ensembl

ENSG00000168685

n/a

UniProt

P16871

P16872

RefSeq (mRNA)

NM_002185

NM_008372
NM_001355680

RefSeq (protein)

NP_002176

NP_032398
NP_001342609

Location (UCSC)Chr 5: 35.85 – 35.88 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin (TSLP) receptors.

References
  1. GRCh38: Ensembl release 89: ENSG00000168685 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: IL7R interleukin 7 receptor".
  5. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865.

Further reading
  • Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848.
  • Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077.
  • Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours". Histol. Histopathol. 18 (3): 911–23. PMID 12792903.
  • Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841.
  • Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13". Leukemia. 6 (7): 662–8. PMID 1378163.
  • Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235.
  • Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter". Mol. Cell. Biol. 11 (6): 3052–9. doi:10.1128/MCB.11.6.3052. PMC 360143. PMID 2038316.
  • Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7". J. Immunol. 153 (1): 97–109. PMID 7515933.
  • van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain". Leukemia. 10 (8): 1317–25. PMID 8709637.
  • Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice". Cell. 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624.
  • Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor". Nature. 391 (6670): 904–7. doi:10.1038/36122. PMID 9495344.
  • Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216.
  • Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor". Immunity. 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656.
  • Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271.
  • Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency". Blood. 96 (8): 2803–7. doi:10.1182/blood.V96.8.2803. PMID 11023514.
  • Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.

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