CD177

CD177 antigen is a protein that in humans is encoded by the CD177 gene.[5][6][7]

CD177
Identifiers
AliasesCD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDsOMIM: 162860 MGI: 1916141 HomoloGene: 49628 GeneCards: CD177
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.31Start43,353,686 bp[1]
End43,363,172 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57126

68891

Ensembl

ENSG00000204936

ENSMUSG00000052212

UniProt

Q8N6Q3

Q8R2S8

RefSeq (mRNA)

NM_020406

NM_026862

RefSeq (protein)

NP_065139

NP_081138

Location (UCSC)Chr 19: 43.35 – 43.36 MbChr 7: 24.74 – 24.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM][7]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000204936 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052212 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL (May 2000). "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera". Blood. 95 (8): 2569–76. PMID 10753836.
  6. Lalezari P, Murphy GB, Allen FH Jr (Jun 1971). "NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia". J Clin Invest. 50 (5): 1108–15. doi:10.1172/JCI106582. PMC 292033. PMID 5552408.
  7. "Entrez Gene: CD177 CD177 molecule".

Further reading
  • Stroncek D (2003). "Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology". Vox Sang. 83 Suppl 1: 359–61. doi:10.1111/j.1423-0410.2002.tb05334.x. PMID 12617169.
  • Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231–6. PMID 12901344.
  • Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
  • Goldschmeding R, van Dalen CM, Faber N, et al. (1992). "Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils". Br. J. Haematol. 81 (3): 336–45. doi:10.1111/j.1365-2141.1992.tb08237.x. PMID 1382544.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Stroncek DF, Herr GP, Plachta LB (1994). "Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions". J. Lab. Clin. Med. 123 (2): 247–55. PMID 8301201.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kissel K, Santoso S, Hofmann C, et al. (2001). "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions". Eur. J. Immunol. 31 (5): 1301–9. doi:10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J. PMID 11465086.
  • Bettinotti MP, Olsen A, Stroncek D (2002). "The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177". Clin. Immunol. 102 (2): 138–44. doi:10.1006/clim.2001.5154. PMID 11846455.
  • Kissel K, Scheffler S, Kerowgan M, Bux J (2002). "Molecular basis of NB1 (HNA-2a, CD177) deficiency". Blood. 99 (11): 4231–3. doi:10.1182/blood.V99.11.4231. PMID 12010833.
  • Klippel S, Strunck E, Busse CE, et al. (2002). "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera". Blood. 100 (7): 2441–8. doi:10.1182/blood-2002-03-0949. PMID 12239154.
  • Teofili L, Martini M, Luongo M, et al. (2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249–54. doi:10.1200/JCO.2002.11.507. PMID 12377969.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Najfeld V, Fuchs S, Merando P, et al. (2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis". Exp. Hematol. 31 (2): 118–21. doi:10.1016/S0301-472X(02)01032-9. PMID 12591276.
  • Wolff J, Brendel C, Fink L, et al. (2003). "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms". Blood. 102 (2): 731–3. doi:10.1182/blood-2002-09-2831. PMID 12623849.
  • Johansson P, Andréasson B, Safai-Kutti S, et al. (2003). "The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia". Eur. J. Haematol. 70 (6): 358–62. doi:10.1034/j.1600-0609.2003.00079.x. PMID 12756017.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.