Glycoprotein IX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[5]

GP9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGP9, CD42a, GPIX, Glycoprotein IX, glycoprotein IX platelet
External IDsOMIM: 173515 MGI: 1860137 HomoloGene: 144 GeneCards: GP9
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q21.3Start129,060,767 bp[1]
End129,062,406 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2815

54368

Ensembl

ENSG00000169704

ENSMUSG00000030054

UniProt

P14770

O88186

RefSeq (mRNA)

NM_000174

NM_018762

RefSeq (protein)

NP_000165

NP_061232

Location (UCSC)Chr 3: 129.06 – 129.06 MbChr 6: 87.78 – 87.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][5]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000169704 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030054 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GP9 glycoprotein IX (platelet)".

Further reading
  • Kunishima S, Kamiya T, Saito H (2003). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. doi:10.1007/BF02982690. PMID 12463594.
  • Hickey MJ, Deaven LL, Roth GJ (1991). "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3". FEBS Lett. 274 (1–2): 189–92. doi:10.1016/0014-5793(90)81361-Q. PMID 2253772.
  • Du X, Beutler L, Ruan C, et al. (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524–7. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691.
  • Andrews RK, Booth WJ, Gorman JJ, et al. (1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–26. doi:10.1021/bi00447a009. PMID 2557900.
  • Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773–7. doi:10.1073/pnas.86.17.6773. PMC 297928. PMID 2771955.
  • Roth GJ, Ozols J, Nugent DJ, Williams SA (1988). "Isolation and characterization of human platelet glycoprotein IX". Biochem. Biophys. Res. Commun. 156 (2): 931–9. doi:10.1016/S0006-291X(88)80933-1. PMID 3056407.
  • Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. doi:10.1074/jbc.270.24.14693. PMID 7782333.
  • Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ (1994). "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX". Blood. 84 (4): 1124–31. doi:10.1182/blood.V84.4.1124.1124. PMID 8049428.
  • Hickey MJ, Roth GJ (1993). "Characterization of the gene encoding human platelet glycoprotein IX". J. Biol. Chem. 268 (5): 3438–43. PMID 8429020.
  • Wright SD, Michaelides K, Johnson DJ, et al. (1993). "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome". Blood. 81 (9): 2339–47. doi:10.1182/blood.V81.9.2339.2339. PMID 8481514.
  • Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood. 87 (4): 1385–95. doi:10.1182/blood.V87.4.1385.bloodjournal8741385. PMID 8608228.
  • Hollmann C, Haag F, Schlott M, et al. (1996). "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products". Mol. Immunol. 33 (9): 807–17. doi:10.1016/0161-5890(96)00008-9. PMID 8811076.
  • Noris P, Simsek S, Stibbe J, von dem Borne AE (1997). "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome". Br. J. Haematol. 97 (2): 312–20. doi:10.1046/j.1365-2141.1997.582706.x. PMID 9163595.
  • Hayashi T, Suzuki K, Yahagi A, et al. (1997). "Corrected DNA sequence of the platelet glycoprotein IX gene". Thromb. Haemost. 77 (5): 1034–5. doi:10.1055/s-0038-1656099. PMID 9184424.
  • Bradford HN, Dela Cadena RA, Kunapuli SP, et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood. 90 (4): 1508–15. doi:10.1182/blood.V90.4.1508. PMID 9269768.
  • Suzuki K, Hayashi T, Yahagi A, et al. (1998). "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome". Br. J. Haematol. 99 (4): 794–800. doi:10.1046/j.1365-2141.1997.4753275.x. PMID 9432024.
  • Noris P, Arbustini E, Spedini P, et al. (1999). "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV". Br. J. Haematol. 103 (4): 1004–13. doi:10.1046/j.1365-2141.1998.01100.x. PMID 9886312.
  • Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. doi:10.1046/j.1432-1327.1999.00467.x. PMID 10429193.
  • Kunishima S, Tomiyama Y, Honda S, et al. (2000). "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome". Br. J. Haematol. 107 (3): 539–45. doi:10.1046/j.1365-2141.1999.01733.x. PMID 10583255.
  • Rivera CE, Villagra J, Riordan M, et al. (2001). "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome". Br. J. Haematol. 112 (1): 105–8. doi:10.1046/j.1365-2141.2001.02529.x. PMID 11167791.

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