Integrin alpha 6

ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6
External IDs	OMIM: 147556 MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	172,506,459 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	71,858,416 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• metal ion binding; • integrin binding; • GO:0001948 protein binding; • laminin binding; • neuregulin binding; • GO:0032403 macromolecular complex binding; • insulin-like growth factor I binding; • cadherin binding;
Cellular component	• integral component of membrane; • membrane; • focal adhesion; • basal part of cell; • cell membrane; • hemidesmosome; • basement membrane; • cell surface; • integrin complex; • basal plasma membrane; • basolateral plasma membrane; • external side of plasma membrane; • integrin alpha6-beta4 complex; • filopodium; • cell-cell adherens junction;
Biological process	• cellular response to extracellular stimulus; • hemidesmosome assembly; • renal system development; • nail development; • positive regulation of cell-cell adhesion; • filopodium assembly; • negative regulation of extrinsic apoptotic signaling pathway; • extracellular matrix organization; • odontogenesis of dentin-containing tooth; • cell-substrate adhesion; • positive regulation of GTPase activity; • cell adhesion; • cell adhesion mediated by integrin; • brown fat cell differentiation; • positive regulation of apoptotic process; • cell-substrate junction assembly; • integrin-mediated signaling pathway; • positive regulation of phosphorylation; • cell-matrix adhesion; • digestive tract development; • ectodermal cell differentiation; • leukocyte migration; • skin development; • positive regulation of transcription from RNA polymerase II promoter; • amelogenesis; • cellular response to organic cyclic compound; • positive regulation of cell-substrate adhesion; • positive regulation of cell migration; • cell-cell adhesion; • positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	3655
	16403
	ENSG00000091409
	ENSMUSG00000027111
	P23229
	Q61739
	NM_000210; NM_001079818; NM_001316306; NM_001365529; NM_001365530
	NM_001277970; NM_008397
	NP_000201; NP_001073286; NP_001303235; NP_001352458; NP_001352459
	NP_001264899; NP_032423
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5]. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]

Interactions

ITGA6 has been shown to interact with TSPAN4[7] and GIPC1.[8]

References

GRCh38: Ensembl release 89: ENSG00000091409 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027111 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ITGA6 integrin, alpha 6".
De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.
Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

External links

CD49f+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
ITGA6 Info with links in the Cell Migration Gateway

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091409 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027111 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: ITGA6 integrin, alpha 6".

[pmid27371534-6] De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.

[pmid9360996-7] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

[pmid11479315-8] Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Integrin alpha 6

Function

Interactions

See also

References

Further reading

External links