KIR2DL4

Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.[3][4]

KIR2DL4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKIR2DL4, CD158D, G9P, KIR-103AS, KIR103, KIR103AS, KIR, KIR-2DL4, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
External IDsOMIM: 604945 HomoloGene: 124412 GeneCards: KIR2DL4
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.42Start54,803,535 bp[1]
End54,814,517 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3805

n/a

Ensembl

n/a

UniProt

Q99706

n/a

RefSeq (mRNA)

NM_002255
NM_001080770
NM_001080772
NM_001258383

n/a

RefSeq (protein)

NP_001074239
NP_001074241
NP_002246

n/a

Location (UCSC)Chr 19: 54.8 – 54.81 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of CD8+ T cells.[5] The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.[4]

The only so far reported ligand of KIR2DL4 is the non-classical HLA class 1 gene HLA-G, leading to the inhibition of the cytolytic NK cell function.[5]

See also

References

  1. ENSG00000278606, ENSG00000277540, ENSG00000273575, ENSG00000275732, ENSG00000275699, ENSG00000275317, ENSG00000284509, ENSG00000277750, ENSG00000284365, ENSG00000275848, ENSG00000275456, ENSG00000274955, ENSG00000277964, ENSG00000277362, ENSG00000276979, ENSG00000283961, ENSG00000277850, ENSG00000284460, ENSG00000278074, ENSG00000277076, ENSG00000274189, ENSG00000276044, ENSG00000276779, ENSG00000277355, ENSG00000283869, ENSG00000278201, ENSG00000278271, ENSG00000275237, ENSG00000189013, ENSG00000273498, ENSG00000274193, ENSG00000278430, ENSG00000274232, ENSG00000274609, ENSG00000284013, ENSG00000283986, ENSG00000284340, ENSG00000284562, ENSG00000284206, ENSG00000284457 GRCh38: Ensembl release 89: ENSG00000274945, ENSG00000278606, ENSG00000277540, ENSG00000273575, ENSG00000275732, ENSG00000275699, ENSG00000275317, ENSG00000284509, ENSG00000277750, ENSG00000284365, ENSG00000275848, ENSG00000275456, ENSG00000274955, ENSG00000277964, ENSG00000277362, ENSG00000276979, ENSG00000283961, ENSG00000277850, ENSG00000284460, ENSG00000278074, ENSG00000277076, ENSG00000274189, ENSG00000276044, ENSG00000276779, ENSG00000277355, ENSG00000283869, ENSG00000278201, ENSG00000278271, ENSG00000275237, ENSG00000189013, ENSG00000273498, ENSG00000274193, ENSG00000278430, ENSG00000274232, ENSG00000274609, ENSG00000284013, ENSG00000283986, ENSG00000284340, ENSG00000284562, ENSG00000284206, ENSG00000284457 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Selvakumar A, Steffens U, Dupont B (October 1996). "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains". Tissue Antigens. 48 (4 Pt 1): 285–94. doi:10.1111/j.1399-0039.1996.tb02647.x. PMID 8946682.
  4. "Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4".
  5. Carosella ED, Favier B, Rouas-Freiss N, Moreau P, Lemaoult J (May 2008). "Beyond the increasing complexity of the immunomodulatory HLA-G molecule". Blood. 111 (10): 4862–70. doi:10.1182/blood-2007-12-127662. PMID 18334671.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)

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