Interleukin-28 receptor

Interleukin-28 receptor is a type II cytokine receptor found in skin cells. It binds interleukin-28 A and B as well as interleukin 29.[1] It consists of an α and shares a common β subunit with the interleukin-10 receptor.[2][3] Binding to the interleukin-28 receptor is important for fighting infection.[4]

interleukin 28 receptor, alpha (interferon, lambda receptor)
Identifiers
SymbolIL28RA
Alt. symbolsCRF2/12, IFNLR, IL-28R1
NCBI gene163702
HGNC18584
OMIM607404
RefSeqNM_170743
UniProtQ8IU57
Other data
LocusChr. 1 p36.11
interleukin 10 receptor, beta
Identifiers
SymbolIL10RB
Alt. symbolsCRFB4, D21S58, D21S66
NCBI gene3588
HGNC5965
OMIM123889
RefSeqNM_000628
UniProtQ08334
Other data
LocusChr. 21 q22.1-22.2

Structure

The interleukin-28 receptor is a complex made up of two protein chains; the interleukin-28 receptor alpha chain and the beta chain from another interleukin receptor (IL-10).[5]

Location

The Interleukin-28 receptor is found in skin cells, specifically keratinocytes and melanocytes found in the epidermis.  It binds to the cytokine interleukin-28 that is produced by immune cells, specifically regulatory T cells and maturing dendritic cells, and other skin cells that have been virally infected.[4]

Function

When the cytokine Interleukin-28 binds to the interleukin-28 receptor it causes several cellular responses that aid the skin cells in fighting infection.  In binding to the receptor interleukin-28 cell growth is inhibited and the cell begins to produce cellular receptors that can sense infection as well as proteins to fight a viral infection. The interleukin-28 receptor, once a ligand is bound will activate a signaling pathway that caused in increase in MHC class 1 production.[4]

References
  1. "IFNLR1 interferon lambda receptor 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-03-11.
  2. Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, et al. (January 2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nature Immunology. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210.
  3. Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, et al. (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nature Immunology. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119.
  4. Wolk K, Witte K, Sabat R (August 2010). "Interleukin-28 and interleukin-29: novel regulators of skin biology". Journal of Interferon & Cytokine Research. 30 (8): 617–28. doi:10.1089/jir.2010.0064. PMID 20712456.
  5. "Figure 1—figure supplement 2. Pfam genome neighborhood network (GNN)". dx.doi.org. Retrieved 2020-03-11.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.