IL13RA2

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[5]

IL13RA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDsOMIM: 300130 MGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq23Start115,003,975 bp[1]
End115,019,977 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3598

16165

Ensembl

ENSG00000123496

ENSMUSG00000031289

UniProt

Q14627

O88786

RefSeq (mRNA)

NM_000640

NM_008356
NM_001306059

RefSeq (protein)

NP_000631

NP_001292988
NP_032382

Location (UCSC)Chr X: 115 – 115.02 MbChr X: 147.38 – 147.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. [6][7][8][9]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000123496 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031289 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".
  6. Fujisawa T, Joshi B, Nakajima A, Puri RK (November 2009). "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research. 69 (22): 8678–85. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609.
  7. Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988.
  8. Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T (February 2019). "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports. 9 (1): 1281. doi:10.1038/s41598-019-39018-3. PMC 6362032. PMID 30718742.
  9. Joshi BH, Plautz GE, Puri RK (March 2000). "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research. 60 (5): 1168–72. PMID 10728667.

Further reading
  • Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE (October 2006). "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". The Journal of Allergy and Clinical Immunology. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
  • Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P (July 1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". The Journal of Biological Chemistry. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
  • Zhang JG, Hilton DJ, Willson TA, McFarlane C, Roberts BA, Moritz RL, Simpson RJ, Alexander WS, Metcalf D, Nicola NA (April 1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". The Journal of Biological Chemistry. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
  • Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T, Eugster HP, Bonnefoy JY (April 1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". European Journal of Immunology. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652.
  • Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S (May 1997). "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics. 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
  • Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O'Hara RM, Beier DR, Turner KJ, Wood CR, Collins M (September 1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". Journal of Immunology. 161 (5): 2317–24. PMID 9725226.
  • Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H (September 2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics. 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391.
  • Kawakami K, Takeshita F, Puri RK (July 2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". The Journal of Biological Chemistry. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
  • Daines MO, Hershey GK (March 2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". The Journal of Biological Chemistry. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
  • Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H (September 2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clinical Cancer Research. 8 (9): 2851–5. PMID 12231526.
  • Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, Jiménez-Zamudio L, García-Latorre E, León-Dorantes G, Blancas-González F, Paredes-Cabrera G, Cancino-Díaz ME (November 2002). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". The Journal of Investigative Dermatology. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
  • David M, Bertoglio J, Pierre J (November 2002). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Annals of the New York Academy of Sciences. 973: 207–9. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861.
  • Wu AH, Low WC (July 2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-Oncology. 5 (3): 179–87. doi:10.1215/s1152851702000510. PMC 1920687. PMID 12816724.
  • Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K (July 2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". The Journal of Biological Chemistry. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
  • Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A (January 2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nature Medicine. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802.
  • Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK (June 2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". Journal of Immunology. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
  • Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988.
  • Granel B, Allanore Y, Chevillard C, Arnaud V, Marquet S, Weiller PJ, Durand JM, Harlé JR, Grange C, Frances Y, Berbis P, Gaudart J, de Micco P, Kahan A, Dessein A (October 2006). "IL13RA2 gene polymorphisms are associated with systemic sclerosis". The Journal of Rheumatology. 33 (10): 2015–9. PMID 16981293.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.